ArticleThe American journal of pathology2000
Transition from squamous cell carcinoma to adenocarcinoma in adenosquamous carcinoma of the lung.
Article in The American journal of pathology, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 56 citations in OpenAlex.
- Article
- TET2-STAT3-CXCL5 nexus promotes neutrophil lipid transfer to fuel lung adeno-to-squamous transition.The Journal of experimental medicine · 2024Article
- Radiomics and deep learning models to differentiate lung adenosquamous carcinoma: A multicenter trial.iScience · 2023Article
- Clonal dynamics and Stereo-seq resolve origin and phenotypic plasticity of adenosquamous carcinoma.NPJ precision oncology · 2023Article
- Adenosquamous carcinoma coexisting with intraductal papillary mucinous neoplasm of the pancreas: a case report.Journal of medical case reports · 2023Article
- Adenocarcinomatous-predominant subtype associated with a better prognosis in adenosquamous lung carcinoma.BMC cancer · 2020Article
- Adenosquamous carcinoma development as a recurrence of squamous cell carcinoma in the oral floor: A case report.Medicine · 2019Article
- Highly invasive and poorly differentiated corneal squamous cell carcinoma in a dog.BMC veterinary research · 2019Article
- Identification of Adenosquamous Carcinoma as a Rare Aggressive HER2-negative Subgroup of Esophageal/Gastroesophageal Junction Adenocarcinoma.American journal of clinical oncology · 2019Article
- High levels of CCL2 or CCL4 in the tumor microenvironment predict unfavorable survival in lung adenocarcinoma.Thoracic cancer · 2018Article
- Adenosquamous carcinoma of the lung.OncoTargets and therapy · 2018Review
- Research progress of the clinicopathologic features of lung adenosquamous carcinoma.OncoTargets and therapy · 2018Review
- Predictive and prognostic value of preoperative serum tumor markers in resectable adenosqamous lung carcinoma.Oncotarget · 2016Article
- Article
- Clinicopathological characteristics and prognosis of patients with adenosquamous lung carcinoma.Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban · 2015Article
- Clinicopathological features and surgical outcomes of adenosquamous carcinoma of the pancreas: a retrospective analysis of patients with resectable stage tumors.Surgery today · 2015Article
- Comprehensive characterization of cancer subtype associated long non-coding RNAs and their clinical implications.Scientific reports · 2014Article
- Clinical significance of PIK3CA and survivin in primary adenosquamous lung carcinoma.Medical oncology (Northwood, London, England) · 2014Article
- Adenosquamous cell lung cancer successfully treated with gefitinib: A case report.Molecular and clinical oncology · 2014Article
- Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The heterogeneity of tumor cells is frequently observed in lung cancer, but the clonality of these cells has not yet been established. The distinct components of 12 lung adenosquamous carcinomas were compared by genetic alterations of p53 and K-ras, chromosomal abnormalities at 9p21 and 9q31-32, and immunohistochemical reactions. The immunoreactivity of p53 was consistent in both adenocarcinomatous and squamous cell carcinomatous components as well as in the transitional areas, retaining the morphological characteristics of the distinct components. The same p53 mutation was found in both components of each tumor with p53 overexpression. No K-ras mutations were detected in any of the tumors examined. Three of the four tumors with chromosomal abnormalities detected, one at 9p21 and two at 9q31-32, had coincident abnormalities between the distinct components, whereas one tumor deleted homozygously at 9p21 (D9S259) in the adenocarcinomatous component with loss of heterozygosity in the other component. The expression of squamous cell carcinoma-related antigen in adenocarcinomatous components was significantly higher than that of lung adenocarcinomas (57 +/- 5.8% vs. 1.0 +/- 0.5%, P < 0.0001), whereas Mucin 1 expression is less in these components (9.0 +/- 4.9% vs. 55 +/- 8.2%, P = 0.003). These results suggest monoclonal transition from squamous cell carcinoma to adenocarcinoma in lung adenosquamous carcinoma.
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