ArticleThe American journal of pathology2000
Tumor necrosis factor induces tumor necrosis via tumor necrosis factor receptor type 1-expressing endothelial cells of the tumor vasculature.
Article in The American journal of pathology, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 64 citations in OpenAlex.
- TNFR1 expression on cancer cells mediates immune escape and an immunosuppressive microenvironment.The Journal of experimental medicine · 2026Article
- Advancing Biologic Therapy for Refractory Autoimmune Hepatitis.Digestive diseases and sciences · 2022Review
- Safe eradication of large established tumors using neovasculature-targeted tumor necrosis factor-based therapies.EMBO molecular medicine · 2020Article
- TNF-α G-308A genetic variants, serum CRP-hs concentration and DNA damage in obese women.Molecular biology reports · 2020Article
- The critical role of novel benzophenone analogs on tumor growth inhibition targeting angiogenesis and apoptosis.MedChemComm · 2018Article
- Trends and advances in tumor immunology and lung cancer immunotherapy.Journal of experimental & clinical cancer research : CR · 2016Review
- TNF Neutralization Results in the Delay of Transplantable Tumor Growth and Reduced MDSC Accumulation.Frontiers in immunology · 2016Article
- Safe TNF-based antitumor therapy following p55TNFR reduction in intestinal epithelium.The Journal of clinical investigation · 2013Article
- Alterations in tumor necrosis factor signaling pathways are associated with cytotoxicity and resistance to taxanes: a study in isogenic resistant tumor cells.Breast cancer research : BCR · 2012Article
- SOD2-mediated adaptive responses induced by low-dose ionizing radiation via TNF signaling and amifostine.Free radical biology & medicine · 2011Article
- Direct crosstalk between mast cell-TNF and TNFR1-expressing endothelia mediates local tissue inflammation.Blood · 2009Article
- Translational strategies exploiting TNF-alpha that sensitize tumors to radiation therapy.Cancer gene therapy · 2009Article
- Chimeric form of tumor necrosis factor-alpha has enhanced surface expression and antitumor activity.Cancer gene therapy · 2009Article
- Thrombospondin-1-induced apoptosis of brain microvascular endothelial cells can be mediated by TNF-R1.Journal of cellular physiology · 2009Article
- Intravital imaging of CD8+ T cell function in cancer.Clinical & experimental metastasis · 2009Review
- IFN-gamma- and TNF-dependent bystander eradication of antigen-loss variants in established mouse cancers.The Journal of clinical investigation · 2008Article
- A comprehensive in vitro characterization of pancreatic ductal carcinoma cell line biological behavior and its correlation with the structural and genetic profile.Virchows Archiv : an international journal of pathology · 2004Article
- Alterations in the apoptotic machinery and their potential role in anticancer drug resistance.Oncogene · 2003Review
- Requirement for tumor necrosis factor receptor 2 expression on vascular cells to induce experimental cerebral malaria.Infection and immunity · 2002Article
- The antitumour activity of 5,6-dimethylxanthenone-4-acetic acid (DMXAA) in TNF receptor-1 knockout mice.British journal of cancer · 2002Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Activation of endothelial cells, fibrin deposition, and coagulation within the tumor vasculature has been shown in vivo to correlate with the occurrence of tumor necrosis factor (TNF)-induced tumor necrosis in mice. In the present study we investigated which target cells mediate the TNF-induced necrosis in fibrosarcomas grown in wild type (wt), TNF receptor type 1-deficient (TNFRp55-/-), and TNF receptor type 2-deficient (TNFRp75-/-) mice. TNF administration resulted in tumor necrosis exclusively in wt and TNFRp75-/-, but not in TNFRp55-/- mice, indicating a dependence of TNF-mediated tumor necrosis on the expression of TNF receptor type 1. However, using wt and TNFRp55-/- fibrosarcomas in wt mice, we found that TNF-mediated tumor necrosis was completely independent of TNF receptor type 1 expression in tumor cells. Thus we could exclude any direct tumoricidal effect of TNF in this model. Soluble TNF induced leukostasis in wt and TNFRp75-/- mice but not in TNFRp55-/- mice. TNF-induced leukostasis in TNFRp55-/- mice was restored by adoptive bone marrow transplantation of wt hematopoietic cells, but TNF failed to induce tumor necrosis in these chimeric mice. Because TNF administration resulted in both activation and focal damage of tumor endothelium, TNF receptor type 1-expressing cells of the tumor vasculature, likely to be endothelial cells, appear to be target cells for mediating TNF-induced tumor necrosis.
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