Evidence map›Paper›PMID 10749918›Full record

ArticleMolecular biology of the cell2000

Functional interactions between the p35 subunit of the Arp2/3 complex and calmodulin in yeast.

C Schaerer-Brodbeck, H Riezman

Open access · greenAbstract read
In one paragraph

Article in Molecular biology of the cell, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
2.3field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 42 citations in OpenAlex.

  1. Article
  2. How to let go: pectin and plant cell adhesion.Frontiers in plant science · 2015
    Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. The ARP2/3 complex: an actin nucleator comes of age.Nature reviews. Molecular cell biology · 2006
    Review
  9. The yeast actin cytoskeleton: from cellular function to biochemical mechanism.Microbiology and molecular biology reviews : MMBR · 2006
    Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Multiple functions of sterols in yeast endocytosis.Molecular biology of the cell · 2002
    Article
  15. Article
  16. Article
  17. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

C Schaerer-BrodbeckBiozentrum of the University of Basel, CH-4056 Basel, Switzerland.
H Riezman
University of Basel · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The end9-1 (arc35-1) mutant was identified as an endocytosis mutant and is a mutant allele of ARC35 that encodes a subunit of the Arp2/3 complex. As for other mutants in the Arp2/3 complex, arc35-1 is defective for endocytosis and organization of the actin cytoskeleton. Both defects can be suppressed by overexpression of calmodulin. Analysis of a collection of temperature-sensitive cmd1 mutants for their ability to suppress either the endocytic defect and/or the actin defect indicates that the two defects are tightly coupled. We demonstrate that Arc35p and Cmd1p interact and that Arc35p is required for cortical localization of calmodulin. This is the first report linking Arp2/3 complex function with calmodulin through which it exercises at least one of its endocytic functions.

Indexed as

Cytoskeletal ProteinsActin-Related Protein 2Actin-Related Protein 3ActinsAllelesBridged Bicyclo Compounds, HeterocyclicCalmodulinCytoskeletonEndocytosisFungal ProteinsMicroscopy, FluorescenceMutationPrecipitin TestsProtein BindingThiazolesThiazolidinesActin-Related Protein 2Actin-Related Protein 3ActinsBridged Bicyclo Compounds, HeterocyclicCalmodulinCytoskeletal ProteinsFungal Proteinslatrunculin AThiazolesThiazolidines

Identifiers

PMID10749918
PMCPMC14835
OpenAlexW2163789947

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.