ArticleThe Journal of experimental medicine2000
Antigen-specific B cell memory: expression and replenishment of a novel b220(-) memory b cell compartment.
Article in The Journal of experimental medicine, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers.
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Who cites it
55 citing papers in PubMed, 165 citations in OpenAlex.
- Innate immunity and training to subvert original antigenic sin by the humoral immune response.eLife · 2025Article
- IgG is an aging factor that drives adipose tissue fibrosis and metabolic decline.Cell metabolism · 2024Article
- Isotype-specific plasma cells express divergent transcriptional programs.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Protection of Quiescence and Longevity of IgG Memory B Cells by Mitochondrial Autophagy.Journal of immunology (Baltimore, Md. : 1950) · 2022Article
- Article
- A late B lymphocyte action in dysfunctional tissue repair following kidney injury and transplantation.Nature communications · 2019Article
- Techniques to Study Antigen-Specific B Cell Responses.Frontiers in immunology · 2019Review
- Regulated DelayedTheranostics · 2019Article
- Do Memory B Cells Form Secondary Germinal Centers? Impact of Antibody Class and Quality of Memory T-Cell Help at Recall.Cold Spring Harbor perspectives in biology · 2018Review
- Evaluation of Antigen-Conjugated Fluorescent Beads to Identify Antigen-Specific B Cells.Frontiers in immunology · 2018Article
- Naïve and memory B cells exhibit distinct biochemical responses following BCR engagement.Immunology and cell biology · 2016Article
- Article
- Antibodies produced in vitro in the detection of periodontal bacteria by using surface plasmon resonance analysis.Clinical and experimental dental research · 2015Article
- Class-switched memory B cells remodel BCRs within secondary germinal centers.Nature immunology · 2015Article
- Article
- Distinct B-cell populations contribute to vaccine antigen-specific antibody production in a transgenic mouse model.Immunology · 2014Article
- In vivo detection of peripherin-specific autoreactive B cells during type 1 diabetes pathogenesis.Journal of immunology (Baltimore, Md. : 1950) · 2014Article
- Article
- TLR2, TLR4 and the MyD88 signaling are crucial for the in vivo generation and the longevity of long-lived antibody-secreting cells.PloS one · 2013Article
- Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
The mechanisms that regulate B cell memory and the rapid recall response to antigen remain poorly defined. This study focuses on the rapid expression of B cell memory upon antigen recall in vivo, and the replenishment of quiescent B cell memory that follows. Based on expression of CD138 and B220, we reveal a unique and major subtype of antigen-specific memory B cells (B220(-)CD138(-)) that are distinct from antibody-secreting B cells (B220(+/)-CD138(+)) and B220(+)CD138(-) memory B cells. These nonsecreting somatically mutated B220(-) memory responders rapidly dominate the splenic response and comprise >95% of antigen-specific memory B cells that migrate to the bone marrow. By day 42 after recall, the predominant quiescent memory B cell population in the spleen (75-85%) and the bone marrow (>95%) expresses the B220(-) phenotype. Upon adoptive transfer, B220(-) memory B cells proliferate to a lesser degree but produce greater amounts of antibody than their B220(+) counterparts. The pattern of cellular differentiation after transfer indicates that B220(-) memory B cells act as stable self-replenishing intermediates that arise from B220(+) memory B cells and produce antibody-secreting cells on rechallenge with antigen. Cell surface phenotype and Ig isotype expression divide the B220(-) compartment into two main subsets with distinct patterns of integrin and coreceptor expression. Thus, we identify new cellular components of B cell memory and propose a model for long-term protective immunity that is regulated by a complex balance of committed memory B cells with subspecialized immune function.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.