ArticleAmerican journal of human genetics2000
High-density genome scan in Crohn disease shows confirmed linkage to chromosome 14q11-12.
Article in American journal of human genetics, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
48 citing papers in PubMed, 3 syntheses or guidelines pooled it, 195 citations in OpenAlex.
- Gene-Environment Interactions in Inflammatory Bowel Disease: A Systematic Review of Human Epidemiologic Studies.Journal of Crohn's & colitis · 2025Pooled it
- Association of the NFKBIA gene polymorphisms with susceptibility to autoimmune and inflammatory diseases: a meta-analysis.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2011Pooled it
- Pooled it
- Review
- Genetic polymorphisms of NFκB1 -94 del/ins ATTG, NFκB1A 2758 A>G and SUMO rs237025 G>A in psoriasis.International journal of health sciences · 2015Article
- Immunogenetic biomarkers in inflammatory bowel diseases: role of the IBD3 region.World journal of gastroenterology · 2014Review
- Gender-specific association of NFKBIA promoter polymorphisms with the risk of sporadic colorectal cancer.Medical oncology (Northwood, London, England) · 2013Article
- Eosinophil associated genes in the inflammatory bowel disease 4 region: correlation to inflammatory bowel disease revealed.World journal of gastroenterology · 2012Article
- Familial aggregation in inflammatory bowel disease: is it genes or environment?World journal of gastroenterology · 2011Review
- NFκB1 and NFκBIA polymorphisms are associated with increased risk for sporadic colorectal cancer in a southern Chinese population.PloS one · 2011Article
- NOD2 polymorphisms in clinical phenotypes of common variable immunodeficiency disorders.Clinical and experimental immunology · 2010Article
- Mapping of multiple susceptibility variants within the MHC region for 7 immune-mediated diseases.Proceedings of the National Academy of Sciences of the United States of America · 2009Article
- The 3'UTR NFKBIA variant is associated with extensive colitis in Hungarian IBD patients.Digestive diseases and sciences · 2009Article
- Inflammatory bowel disease: review from the aspect of genetics.Journal of gastroenterology · 2009Review
- Defining the role of the MHC in autoimmunity: a review and pooled analysis.PLoS genetics · 2008Review
- From model cell line to in vivo gene expression: disease-related intestinal gene expression in IBD.Genes and immunity · 2008Article
- Gene-centric association mapping of chromosome 3p implicates MST1 in IBD pathogenesis.Mucosal immunology · 2008Article
- An SNP linkage scan identifies significant Crohn's disease loci on chromosomes 13q13.3 and, in Jewish families, on 1p35.2 and 3q29.Genes and immunity · 2008Article
- Novel genetic markers in inflammatory bowel disease.World journal of gastroenterology · 2007Review
- TNFSF15 is an ethnic-specific IBD gene.Inflammatory bowel diseases · 2007Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Epidemiological studies have shown that genetic factors contribute to the pathogenesis of the idiopathic inflammatory bowel diseases (IBD), Crohn disease (CD) and ulcerative colitis (UC). Recent genome scans and replication studies have identified replicated linkage between CD and a locus on chromosome 16 (the IBD1 locus), replicated linkage between IBD (especially UC) and a locus on chromosome 12q (the IBD2 locus), and replicated linkage between IBD (especially CD) and a locus on chromosome 6p (the IBD3 locus). Since the estimated locus-specific lambdas values for the regions of replicated linkage do not account for the overall lambdas in CD, and since the published genome scans in IBD show at least nominal evidence for linkage to regions on all but two chromosomes, we performed an independent genome scan using 751 microsatellite loci in 127 CD-affected relative pairs from 62 families. Single-point nonparametric linkage analysis using the GENEHUNTER-PLUS program shows evidence for linkage to the adjacent D14S261 and D14S283 loci on chromosome 14q11-12 (LOD = 3.00 and 1.70, respectively), and the maximal multipoint LOD score is observed at D14S261 (LOD = 3.60). In the multipoint analysis, nominal evidence for linkage (P<.05) is observed near D2S117 (LOD = 1.25), near D3S3045 (LOD = 1.31), between D7S40 and D7S648 (LOD = 0.91), and near D18S61 (LOD = 1.15). Our finding of significant linkage to D14S261 and the finding of suggestive linkage to the same locus in an independent study (multipoint LOD = 2.8) satisfies criteria for confirmed linkage, so we propose that the region of interest on chromosome 14q11-12 should be designated the IBD4 locus.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.