ArticleThe Journal of cell biology2000
Evidence for the involvement of KIF4 in the anterograde transport of L1-containing vesicles.
Article in The Journal of cell biology, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 78 citations in OpenAlex.
- The post-stroke young adult brain has limited capacity to re-express the gene expression patterns seen during early postnatal brain development.Brain pathology (Zurich, Switzerland) · 2024Article
- Dual spatio-temporal regulation of axon growth and microtubule dynamics by RhoA signaling pathways.Journal of cell science · 2024Article
- FREEDA: An automated computational pipeline guides experimental testing of protein innovation.The Journal of cell biology · 2023Article
- Phenotype, genotype, and management of congenital fibrosis of extraocular muscles type 1 in 16 Chinese families.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2023Article
- FREEDA: an automated computational pipeline guides experimental testing of protein innovation by detecting positive selection.bioRxiv : the preprint server for biology · 2023Article
- The kinesin KIF4 mediates HBV/HDV entry through the regulation of surface NTCP localization and can be targeted by RXR agonists in vitro.PLoS pathogens · 2022Article
- Expanding the KIF4A-associated phenotype.American journal of medical genetics. Part A · 2021Article
- Mutations in the KIF21B kinesin gene cause neurodevelopmental disorders through imbalanced canonical motor activity.Nature communications · 2020Article
- Altered chemomechanical coupling causes impaired motility of the kinesin-4 motors KIF27 and KIF7.The Journal of cell biology · 2018Article
- Reciprocal Interactions between Cell Adhesion Molecules of the Immunoglobulin Superfamily and the Cytoskeleton in Neurons.Frontiers in cell and developmental biology · 2016Review
- Kif4 interacts with EB1 and stabilizes microtubules downstream of Rho-mDia in migrating fibroblasts.PloS one · 2014Article
- Kinesin superfamily motor proteins and intracellular transport.Nature reviews. Molecular cell biology · 2009Review
- KIF4 mediates anterograde translocation and positioning of ribosomal constituents to axons.The Journal of biological chemistry · 2009Article
- The cleavage products of amyloid-beta precursor protein are sorted to distinct carrier vesicles that are independently transported within neurites.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2009Article
- Kinesin KIF4 regulates intracellular trafficking and stability of the human immunodeficiency virus type 1 Gag polyprotein.Journal of virology · 2008Article
- Midbodies and phragmoplasts: analogous structures involved in cytokinesis.Trends in cell biology · 2005Review
- Loss of KLP-19 polar ejection force causes misorientation and missegregation of holocentric chromosomes.The Journal of cell biology · 2004Article
- Dissection of the mammalian midbody proteome reveals conserved cytokinesis mechanisms.Science (New York, N.Y.) · 2004Article
- LIMK1 regulates Golgi dynamics, traffic of Golgi-derived vesicles, and process extension in primary cultured neurons.Molecular biology of the cell · 2004Article
- Identification and phylogenetic analysis of Dictyostelium discoideum kinesin proteins.BMC genomics · 2003Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In this study we present evidence about the cellular functions of KIF4. Using subcellular fractionation techniques and immunoisolation, we have now identified a type of vesicle that associates with KIF4, an NH(2)-terminal globular motor domain kinesin-like protein. This vesicle is highly concentrated in growth cones and contains L1, a cell adhesion molecule implicated in axonal elongation. It lacks synaptic vesicle markers, receptors for neurotrophins, and membrane proteins involved in growth cone guidance. In cultured neurons, KIF4 and L1 predominantly localize to the axonal shaft and its growth cone. Suppression of KIF4 with antisense oligonucleotides results in the accumulation of L1 within the cell body and in its complete disappearance from axonal tips. In addition, KIF4 suppression prevents L1-enhanced axonal elongation. Taken collectively, our results suggest an important role for KIF4 during neuronal development, a phenomenon which may be related to the anterograde transport of L1-containing vesicles.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.