ArticleGenetics2000
The end of the LINE?: lack of recent L1 activity in a group of South American rodents.
Article in Genetics, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
41 citing papers in PubMed, 80 citations in OpenAlex.
- Characterization of repetitive DNA on the genome of the marsh rat Holochilus nanus (Cricetidae: Sigmodontinae).Molecular genetics and genomics : MGG · 2023Article
- Bone structural, biomechanical, and histomorphometric characteristics of the hindlimb skeleton in the marsh rice rat (Oryzomys palustris).Anatomical record (Hoboken, N.J. : 2007) · 2022Article
- Genomic Organization of Microsatellites andAnimals : an open access journal from MDPI · 2022Article
- Article
- Flying Around in the Genome: Characterization of LINE-1 in Chiroptera.Special publications (Texas Tech University. Museum) · 2019Article
- Article
- Contrasted patterns of evolution of the LINE-1 retrotransposon in perissodactyls: the history of a LINE-1 extinction.Mobile DNA · 2018Article
- Resolving kangaroo phylogeny and overcoming retrotransposon ascertainment bias.Scientific reports · 2017Article
- Chromosomal Evolution in Chiroptera.Genes · 2017Review
- Comparative Genomic In Situ Hybridization and the Possible Role of Retroelements in the Karyotypic Evolution of Three Akodontini Species.International journal of genomics · 2017Article
- Evolution and Diversity of Transposable Elements in Vertebrate Genomes.Genome biology and evolution · 2017Review
- LINEs between Species: Evolutionary Dynamics of LINE-1 Retrotransposons across the Eukaryotic Tree of Life.Genome biology and evolution · 2016Article
- When Genomics Is Not Enough: Experimental Evidence for a Decrease in LINE-1 Activity During the Evolution of Australian Marsupials.Genome biology and evolution · 2016Article
- LINE-1 distribution in six rodent genomes follow a species-specific pattern.Journal of genetics · 2016Article
- Evolutionary histories of transposable elements in the genome of the largest living marsupial carnivore, the Tasmanian devil.Molecular biology and evolution · 2015Article
- LINE-1 retrotransposons: from 'parasite' sequences to functional elements.Journal of applied genetics · 2015Article
- Reviving the dead: history and reactivation of an extinct l1.PLoS genetics · 2014Article
- Transposable elements and viruses as factors in adaptation and evolution: an expansion and strengthening of the TE-Thrust hypothesis.Ecology and evolution · 2012Article
- Article
- Retrofitting the genome: L1 extinction follows endogenous retroviral expansion in a group of muroid rodents.Journal of virology · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
L1s (LINE-1: Long Interspersed Nuclear Element 1) are present in all mammals examined to date. They occur in both placental mammals and marsupials and thus are thought to have been present in the genome prior to the mammalian radiation. This unusual conservation of a transposable element family for over 100 million years has led to speculation that these elements provide an advantage to the genomes they inhabit. We have recently identified a group of South American rodents, including rice rats (Oryzomys), in which L1s appear to be quiescent or extinct. Several observations support this conclusion. First, genomic Southern blot analysis fails to reveal genus-specific bands in Oryzomys. Second, we were unable to find recently inserted elements. Procedures to enrich for young elements did not yield any with an intact open reading frame for reverse transcriptase; all elements isolated had numerous insertions, deletions, and stop codons. Phylogenetic analysis failed to yield species-specific clusters among the L1 elements isolated, and all Oryzomys sequences had numerous private mutations. Finally, in situ hybridization of L1 to Oryzomys chromosomes failed to reveal the characteristic L1 distribution in Oryzomys with either a homologous or heterologous probe. Thus, Oryzomys is a viable candidate for L1 extinction from a mammalian host.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.