ArticleGenetics2000
The Drosophila melanogaster hybrid male rescue gene causes inviability in male and female species hybrids.
Article in Genetics, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
49 citing papers in PubMed, 109 citations in OpenAlex.
- Temperature affects conspecific and heterospecific mating rates inAnimal behaviour · 2025Article
- Molecular Insights into Female Hybrid Sterility in Interspecific Crosses betweenInternational journal of molecular sciences · 2024Article
- A new hybrid incompatibility locus between Drosophila melanogaster and Drosophila sechellia.Genetics · 2024Article
- Testing the Drosophila maternal haploid gene for functional divergence and a role in hybrid incompatibility.G3 (Bethesda, Md.) · 2022Article
- Divergence of X-linked trans regulatory proteins and the misexpression of gene targets in sterile Drosophila pseudoobscura hybrids.BMC genomics · 2022Article
- Defective Satellite DNA Clustering into Chromocenters Underlies Hybrid Incompatibility in Drosophila.Molecular biology and evolution · 2021Article
- Evaluation ofJournal of genetics · 2020Article
- Review
- Stonewall and Brickwall: Two Partially Redundant Determinants Required for the Maintenance of Female Germline inG3 (Bethesda, Md.) · 2018Article
- Increased proteomic complexity inScience advances · 2018Article
- Moving Speciation Genetics Forward: Modern Techniques Build on Foundational Studies inGenetics · 2017Review
- The Effect of Temperature onG3 (Bethesda, Md.) · 2017Article
- Evolution and Molecular Control of Hybrid Incompatibility in Plants.Frontiers in plant science · 2016Review
- Speciation and reduced hybrid female fertility in house mice.Evolution; international journal of organic evolution · 2015Article
- Reproductive isolation of hybrid populations driven by genetic incompatibilities.PLoS genetics · 2015Article
- A screen for F1 hybrid male rescue reveals no major-effect hybrid lethality loci in the Drosophila melanogaster autosomal genome.G3 (Bethesda, Md.) · 2014Article
- Limited gene misregulation is exacerbated by allele-specific upregulation in lethal hybrids between Drosophila melanogaster and Drosophila simulans.Molecular biology and evolution · 2014Article
- High-resolution mapping reveals hundreds of genetic incompatibilities in hybridizing fish species.eLife · 2014Article
- Fine mapping of dominant X-linked incompatibility alleles in Drosophila hybrids.PLoS genetics · 2014Article
- The Hmr and Lhr hybrid incompatibility genes suppress a broad range of heterochromatic repeats.PLoS genetics · 2014Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The Drosophila melanogaster mutation Hmr rescues inviable hybrid sons from the cross of D. melanogaster females to males of its sibling species D. mauritiana, D. simulans, and D. sechellia. We have extended previous observations that hybrid daughters from this cross are poorly viable at high temperatures and have shown that this female lethality is suppressed by Hmr and the rescue mutations In(1)AB and D. simulans Lhr. Deficiencies defined here as Hmr(-) also suppressed lethality, demonstrating that reducing Hmr(+) activity can rescue otherwise inviable hybrids. An Hmr(+) duplication had the opposite effect of reducing the viability of female and sibling X-male hybrid progeny. Similar dose-dependent viability effects of Hmr were observed in the reciprocal cross of D. simulans females to D. melanogaster males. Finally, Lhr and Hmr(+) were shown to have mutually antagonistic effects on hybrid viability. These data suggest a model where the interaction of sibling species Lhr(+) and D. melanogaster Hmr(+) causes lethality in both sexes of species hybrids and in both directions of crossing. Our results further suggest that a twofold difference in Hmr(+) dosage accounts in part for the differential viability of male and female hybrid progeny, but also that additional, unidentified genes must be invoked to account for the invariant lethality of hybrid sons of D. melanogaster mothers. Implications of our findings for understanding Haldane's rule-the observation that hybrid breakdown is often specific to the heterogametic sex-are also discussed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.