ArticleGenetics2000
Neutral evolution of the sex-determining gene transformer in Drosophila.
Article in Genetics, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- Molecular evolution and genetic diversity of defective chorion 1 in Anastrepha fraterculus and Anastrepha obliqua (Diptera, Tephritidae).Development genes and evolution · 2024Article
- Identification of sex determination genes and their evolution in Phlebotominae sand flies (Diptera, Nematocera).BMC genomics · 2019Article
- Embryonic lethality is not sufficient to explain hourglass-like conservation of vertebrate embryos.EvoDevo · 2018Article
- The Calibrated Phylogeny of the Drosophila fasciola Subgroup (D. repleta Group Wasserman) Indicates Neogene Diversification of Its Internal Branches.Neotropical entomology · 2017Article
- The comparative study of five sex-determining proteins across insects unveils high rates of evolution at basal components of the sex determination cascade.Development genes and evolution · 2015Article
- Drosophila americana as a model species for comparative studies on the molecular basis of phenotypic variation.Genome biology and evolution · 2013Article
- Positive and purifying selection influence the evolution of doublesex in the Anastrepha fraterculus species group.PloS one · 2012Article
- The gene transformer-2 of Sciara (Diptera, Nematocera) and its effect on Drosophila sexual development.BMC developmental biology · 2011Article
- Function and evolution of sex determination mechanisms, genes and pathways in insects.BioEssays : news and reviews in molecular, cellular and developmental biology · 2011Review
- Evidence for positive selection in the gene fruitless in Anastrepha fruit flies.BMC evolutionary biology · 2010Article
- Use of a regulatory mechanism of sex determination in pest insect control.Journal of genetics · 2010Article
- Origin of a function by tandem gene duplication limits the evolutionary capability of its sister copy.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
- The gene transformer-2 of Anastrepha fruit flies (Diptera, Tephritidae) and its evolution in insects.BMC evolutionary biology · 2010Article
- The gene transformer of anastrepha fruit flies (Diptera, tephritidae) and its evolution in insects.PloS one · 2007Article
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- Functional divergence caused by ancient positive selection of a Drosophila hybrid incompatibility locus.PLoS biology · 2004Article
- Sequence differentiation associated with an inversion on the neo-X chromosome of Drosophila americana.Genetics · 2003Article
- Article
- Population genetics of Caenorhabditis elegans: the paradox of low polymorphism in a widespread species.Genetics · 2003Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The amino acid sequence of the transformer (tra) gene exhibits an extremely rapid rate of evolution among Drosophila species, although the gene performs a critical step in sex determination. These changes in amino acid sequence are the result of either natural selection or neutral evolution. To differentiate between selective and neutral causes of this evolutionary change, analyses of both intraspecific and interspecific patterns of molecular evolution of tra gene sequences are presented. Sequences of 31 tra alleles were obtained from Drosophila americana. Many replacement and silent nucleotide variants are present among the alleles; however, the distribution of this sequence variation is consistent with neutral evolution. Sequence evolution was also examined among six species representative of the genus Drosophila. For most lineages and most regions of the gene, both silent and replacement substitutions have accumulated in a constant, clock-like manner. In exon 3 of D. virilis and D. americana we find evidence for an elevated rate of nonsynonymous substitution, but no statistical support for a greater rate of nonsynonymous relative to synonymous substitutions. Both levels of analysis of the tra sequence suggest that, although the gene is evolving at a rapid pace, these changes are neutral in function.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.