ArticleGenetics2000
The Drosophila wispy gene is required for RNA localization and other microtubule-based events of meiosis and early embryogenesis.
Article in Genetics, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
19 citing papers in PubMed, 31 citations in OpenAlex.
- Article
- Modulating the bicoid gradient in space and time.Hereditas · 2021Article
- Coordination of Embryogenesis by the Centrosome in Drosophila melanogaster.Results and problems in cell differentiation · 2019Review
- Maternal Proteins That Are Phosphoregulated upon Egg Activation Include Crucial Factors for Oogenesis, Egg Activation and Embryogenesis inG3 (Bethesda, Md.) · 2018Article
- Review
- Sperm morphology and the evolution of intracellular sperm-egg interactions.Ecology and evolution · 2018Article
- Female Meiosis: Synapsis, Recombination, and Segregation inGenetics · 2018Review
- The Maternal-to-Zygotic Transition During Vertebrate Development: A Model for Reprogramming.Current topics in developmental biology · 2015Review
- Adenylation of maternally inherited microRNAs by Wispy.Molecular cell · 2014Article
- Translational control of the oogenic program by components of OMA ribonucleoprotein particles in Caenorhabditis elegans.Genetics · 2014Article
- Anastral spindle assembly and γ-tubulin in Drosophila oocytes.BMC cell biology · 2011Article
- Dynamic isomiR regulation in Drosophila development.RNA (New York, N.Y.) · 2010Article
- PAP- and GLD-2-type poly(A) polymerases are required sequentially in cytoplasmic polyadenylation and oogenesis in Drosophila.Development (Cambridge, England) · 2008Article
- Wispy, the Drosophila homolog of GLD-2, is required during oogenesis and egg activation.Genetics · 2008Article
- Spindle assembly in the oocytes of mouse and Drosophila--similar solutions to a problem.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2007Review
- Assembly pathway of the anastral Drosophila oocyte meiosis I spindle.Journal of cell science · 2005Article
- Identifying spatially similar gene expression patterns in early stage fruit fly embryo images: binary feature versus invariant moment digital representations.BMC bioinformatics · 2004Article
- Regulation of maternal transcript destabilization during egg activation in Drosophila.Genetics · 2003Article
- subito encodes a kinesin-like protein required for meiotic spindle pole formation in Drosophila melanogaster.Genetics · 2002Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
RNAs are localized by microtubule-based pathways to both the anterior and posterior poles of the developing Drosophila oocyte. We describe a new gene, wispy, required for localization of mRNAs to both poles of the egg. Embryos from wispy mothers arrest development after abnormal oocyte meiosis and failure of pronuclei to fuse. Our analysis of spindle and chromosome movements during meiosis reveals defects in spindle structures correlated with very high frequencies of chromosome nondisjunction and loss. Spindle defects include abnormally shaped spindles, spindle spurs, and ectopic spindles associated with lost chromosomes, as well as mispositioning of the meiosis II spindles. The polar body nuclei do not associate with their normal monastral arrays of microtubules, the sperm aster is reduced in size, and the centrosomes often dissociate from a mitotic spindle that forms in association with the male pronucleus. We show that wispy is required to recruit or maintain known centrosomal proteins with two types of microtubule organizing centers (MTOCs): (1) the central MTOC that forms between the meiosis II tandem spindles and (2) the centrosomes of the mitotic spindle. We propose that the wispy gene product functions directly in several microtubule-based events in meiosis and early embryogenesis and speculate about its possible mode of action.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.