ArticleGenetics2000
RAD51 is required for propagation of the germinal nucleus in Tetrahymena thermophila.
Article in Genetics, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed, 27 citations in OpenAlex.
- OsRAD51 Plays a Vital Role in Promoting Homologous Recombination in Rice Meiosis.International journal of molecular sciences · 2022Article
- Disruption of a ∼23-24 nucleotide small RNA pathway elevates DNA damage responses inMolecular biology of the cell · 2021Article
- An Optimized and Versatile Counter-Flow Centrifugal Elutriation Workflow to Obtain Synchronized Eukaryotic Cells.Frontiers in cell and developmental biology · 2021Article
- Total internal reflection fluorescence microscopy of intraflagellar transport in Tetrahymena thermophila.Methods in cell biology · 2015Article
- Developmental regulation of the Tetrahymena thermophila origin recognition complex.PLoS genetics · 2015Article
- Three steps to the immortality of cancer cells: senescence, polyploidy and self-renewal.Cancer cell international · 2013Article
- The recombinases Rad51 and Dmc1 play distinct roles in DNA break repair and recombination partner choice in the meiosis of Tetrahymena.PLoS genetics · 2011Article
- Nested genes CDA12 and CDA13 encode proteins associated with membrane trafficking in the ciliate Tetrahymena thermophila.Eukaryotic cell · 2009Article
- Abnormal micronuclear telomeres lead to an unusual cell cycle checkpoint and defects in Tetrahymena oral morphogenesis.Eukaryotic cell · 2008Article
- A class II histone deacetylase acts on newly synthesized histones in Tetrahymena.Eukaryotic cell · 2008Article
- Deposition and function of histone H3 variants in Tetrahymena thermophila.Molecular and cellular biology · 2006Article
- The condensin complex is essential for amitotic segregation of bulk chromosomes, but not nucleoli, in the ciliate Tetrahymena thermophila.Molecular and cellular biology · 2006Article
- TIF1 Represses rDNA replication initiation, but promotes normal S phase progression and chromosome transmission in Tetrahymena.Molecular biology of the cell · 2005Article
- A beta-tubulin mutation selectively uncouples nuclear division and cytokinesis in Tetrahymena thermophila.Eukaryotic cell · 2004Article
- The Arabidopsis AtRAD51 gene is dispensable for vegetative development but required for meiosis.Proceedings of the National Academy of Sciences of the United States of America · 2004Article
- Transcriptional control of RAD51 expression in the ciliate Tetrahymena thermophila.Nucleic acids research · 2004Article
- Gain- and loss-of-function of Rhp51, a Rad51 homolog in fission yeast, reveals dissimilarities in chromosome integrity.Nucleic acids research · 2001Article
- Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
RAD51, the eukaryote homolog of the Escherichia coli recA recombinase, participates in homologous recombination during mitosis, meiosis, and in the repair of double-stranded DNA breaks. The Tetrahymena thermophila RAD51 gene was recently cloned, and the in vitro activities and induction of Rad51p following DNA damage were shown to be similar to that of RAD51 from other species. This study describes the pattern of Tetrahymena RAD51 expression during both the cell cycle and conjugation. Tetrahymena RAD51 mRNA abundance is elevated during macronuclear S phase during vegetative cell growth and with both meiotic prophase and new macronuclear development during conjugation. Gene disruption of the macronuclear RAD51 locus leads to severe abnormalities during both vegetative growth and conjugation. rad51 nulls divide slowly and incur rapid deterioration of their micronuclear chromosomes. Conjugation of two rad51 nulls leads to an arrest early during prezygotic development (meiosis I). We discuss the potential usefulness of the ciliates' characteristic nuclear duality for further analyses of the potentially unique roles of Tetrahymena RAD51.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.