ArticleGenetics2000
Evidence that stationary-phase hypermutation in the Escherichia coli chromosome is promoted by recombination.
Article in Genetics, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed.
- Stress-Induced Mutagenesis, Gambler Cells, and Stealth Targeting Antibiotic-Induced Evolution.mBio · 2022Review
- Versioning biological cells for trustworthy cell engineering.Nature communications · 2022Article
- Role of Mfd and GreA in Bacillus subtilis Base Excision Repair-Dependent Stationary-Phase Mutagenesis.Journal of bacteriology · 2020Article
- What is mutation? A chapter in the series: How microbes "jeopardize" the modern synthesis.PLoS genetics · 2019Review
- Stress-Induced Mutagenesis: Implications in Cancer and Drug Resistance.Annual review of cancer biology · 2017Article
- The Origin of Mutants Under Selection: How Natural Selection Mimics Mutagenesis (Adaptive Mutation).Cold Spring Harbor perspectives in biology · 2015Review
- Stress-Induced Mutagenesis.EcoSal Plus · 2012Article
- Two mechanisms produce mutation hotspots at DNA breaks in Escherichia coli.Cell reports · 2012Article
- Sexual isolation in Acinetobacter baylyi is locus-specific and varies 10,000-fold over the genome.Genetics · 2009Article
- Mutability and importance of a hypermutable cell subpopulation that produces stress-induced mutants in Escherichia coli.PLoS genetics · 2008Article
- Novel role of mfd: effects on stationary-phase mutagenesis in Bacillus subtilis.Journal of bacteriology · 2006Article
- Article
- Adaptive point mutation and adaptive amplification pathways in the Escherichia coli Lac system: stress responses producing genetic change.Journal of bacteriology · 2004Article
- General stress response regulator RpoS in adaptive mutation and amplification in Escherichia coli.Genetics · 2004Article
- The roles of REV3 and RAD57 in double-strand-break-repair-induced mutagenesis of Saccharomyces cerevisiae.Genetics · 2002Article
- Adaptive, or stationary-phase, mutagenesis, a component of bacterial differentiation in Bacillus subtilis.Journal of bacteriology · 2002Article
- Phylogenetic and functional analysis of the bacteriophage P1 single-stranded DNA-binding protein.Journal of virology · 2002Article
- Amplification-mutagenesis: evidence that "directed" adaptive mutation and general hypermutability result from growth with a selected gene amplification.Proceedings of the National Academy of Sciences of the United States of America · 2002Article
- Stress-induced evolution and the biosafety of genetically modified microorganisms released into the environment.Journal of biosciences · 2001Review
- Stationary-phase mutation in the bacterial chromosome: recombination protein and DNA polymerase IV dependence.Proceedings of the National Academy of Sciences of the United States of America · 2001Article
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4 authors.
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Abstract
Adaptive (or stationary-phase) mutation is a group of phenomena in which mutations appear to occur more often when selected than when not. They may represent cellular responses to the environment in which the genome is altered to allow survival. The best-characterized assay system and mechanism is reversion of a lac allele on an F' sex plasmid in Escherichia coli, in which the stationary-phase mutability requires homologous recombination functions. A key issue has concerned whether the recombination-dependent mutation mechanism is F' specific or is general. Hypermutation of chromosomal genes occurs in association with adaptive Lac(+) mutation. Here we present evidence that the chromosomal hypermutation is promoted by recombination. Hyperrecombinagenic recD cells show elevated chromosomal hypermutation. Further, recG mutation, which promotes accumulation of recombination intermediates proposed to prime replication and mutation, also stimulates chromosomal hypermutation. The coincident mutations at lac (on the F') and chromosomal genes behave as independent events, whereas coincident mutations at lac and other F-linked sites do not. This implies that transient covalent linkage of F' and chromosomal DNA (Hfr formation) does not underlie chromosomal mutation. The data suggest that recombinational stationary-phase mutation occurs in the bacterial chromosome and thus can be a general strategy for programmed genetic change.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.