ArticleThe EMBO journal2000
Hsp90 is required for c-Mos activation and biphasic MAP kinase activation in Xenopus oocytes.
Article in The EMBO journal, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 66 citations in OpenAlex.
- Transcriptome analysis of Schizothorax oconnori (Cypriniformes: Cyprinidae) oocytes: The role of KFish physiology and biochemistry · 2024Article
- Article
- Heat shock protein 90α couples with the MAPK-signaling pathway to determine meiotic maturation of porcine oocytes.Journal of animal science · 2018Article
- Geldanamycin selectively targets the nascent form of ERBB3 for degradation.Cell stress & chaperones · 2010Article
- Correlation between clinicopathology and expression of heat shock protein 72 and glycoprotein 96 in human esophageal squamous cell carcinoma.Clinical & developmental immunology · 2010Article
- Kicked by Mos and tuned by MPF-the initiation of the MAPK cascade in Xenopus oocytes.HFSP journal · 2009Article
- Mammalian heat shock factor 1 is essential for oocyte meiosis and directly regulates Hsp90alpha expression.The Journal of biological chemistry · 2009Article
- Cloning of cytoplasmic heat shock protein 90 (FcHSP90) from Fenneropenaeus chinensis and its expression response to heat shock and hypoxia.Cell stress & chaperones · 2009Article
- Translational control by cytoplasmic polyadenylation in Xenopus oocytes.Biochimica et biophysica acta · 2008Review
- Deciphering the H-Ras pathway in Xenopus oocyte.Oncogene · 2006Article
- Correlation between clinicopathology and expression of heat shock protein 70 and glucose-regulated protein 94 in human colonic adenocarcinoma.World journal of gastroenterology · 2005Article
- Requirement of Hsp90 activity for IkappaB kinase (IKK) biosynthesis and for constitutive and inducible IKK and NF-kappaB activation.Oncogene · 2004Article
- Xp38gamma/SAPK3 promotes meiotic G(2)/M transition in Xenopus oocytes and activates Cdc25C.The EMBO journal · 2003Article
- A novel regulatory element determines the timing of Mos mRNA translation during Xenopus oocyte maturation.The EMBO journal · 2002Article
- Identification of protein tyrosine phosphatase 1B and casein as substrates for 124-v-Mos.BMC biochemistry · 2002Article
- Cyclin B/cdc2 induces c-Mos stability by direct phosphorylation in Xenopus oocytes.Molecular biology of the cell · 2001Article
- Hsp90: a specialized but essential protein-folding tool.The Journal of cell biology · 2001Review
- Increased histone acetyltransferase and lysine acetyltransferase activity and biphasic activation of the ERK/RSK cascade in insular cortex during novel taste learning.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2001Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
During Xenopus oocyte maturation, the Mos protein kinase is synthesized and activates the MAP kinase cascade. In this report, we demonstrate that the synthesis and activation of Mos are two separable processes. We find that Hsp90 function is required for activation and phosphorylation of Mos and full activation of the MAP kinase cascade. Once Mos is activated, Hsp90 function is no longer required. We show that Mos interacts with both Hsp90 and Hsp70, and that there is an inverse relationship between association of Mos with these two chaperones. We propose that Mos protein kinase is activated by a novel mechanism involving sequential association with Hsp70 and Hsp90 as well as phosphorylation. We also present evidence for a two-phase activation of MAP kinase in Xenopus oocytes.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.