ArticleScience (New York, N.Y.)2000
T cell-independent rescue of B lymphocytes from peripheral immune tolerance.
Article in Science (New York, N.Y.), 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 66 citations in OpenAlex.
- Joint Tissues: Convergence and Divergence of the Pathogenetic Mechanisms of Rheumatoid Arthritis and Osteoarthritis.International journal of molecular sciences · 2025Review
- The Pathophysiological Role of Mitochondrial Oxidative Stress in Rheumatic Diseases.Journal of inflammation research · 2025Review
- Hepatitis B core-based virus-like particles: A platform for vaccine development in plants.Biotechnology reports (Amsterdam, Netherlands) · 2021Review
- A Journey to the Conformational Analysis of T-Cell Epitope Peptides Involved in Multiple Sclerosis.Brain sciences · 2020Review
- Article
- Immunological tolerance as a barrier to protective HIV humoral immunity.Current opinion in immunology · 2017Review
- Reversing Tolerance in Isotype Switch-Competent Anti-Insulin B Lymphocytes.Journal of immunology (Baltimore, Md. : 1950) · 2015Article
- Polyreactivity and autoreactivity among HIV-1 antibodies.Journal of virology · 2015Article
- Virus-like particles: the new frontier of vaccines for animal viral infections.Veterinary immunology and immunopathology · 2012Review
- Immunization with M2e-displaying T7 bacteriophage nanoparticles protects against influenza A virus challenge.PloS one · 2012Article
- Liver-expressed Igkappa superantigen induces tolerance of polyclonal B cells by clonal deletion not kappa to lambda receptor editing.The Journal of experimental medicine · 2011Article
- Lack of patent liver autoimmunity after breakage of tolerance in a mouse model.International immunology · 2003Article
- Visualization of the genesis and fate of isotype-switched B cells during a primary immune response.The Journal of experimental medicine · 2003Article
- Antibodies to 70 kD and 90 kD heat shock proteins are associated with graft-versus-host disease in peripheral blood stem cell transplant recipients.Clinical and experimental immunology · 2002Article
- Maintenance and loss of self-tolerance in B cells.Springer seminars in immunopathology · 2001Review
- Antigen-specific responses in autoimmunity and tolerance.Immunologic research · 2001Review
- Neutralizing antiviral antibody responses.Advances in immunology · 2001Review
- Virus-like particle-based vaccines for animal viral infections.Inmunologia (Barcelona, Spain : 1987)Review
- Immunogenicity of therapeutic proteins: influence of aggregation.Journal of immunotoxicologyReview
Corrections and comments
- Comment on
Authors and funding
3 authors at 3 institutions in 1 country.
Funding
Abstract
Autoimmunity arises when immune tolerance to specific self-antigens is broken. The mechanisms leading to such a failure remain poorly understood. One hypothesis proposes that infectious agents or antigens can break B or T lymphocyte self-tolerance by expressing epitopes that mimic self. Using a transgenic immunoglobulin model, we show that challenge with self-mimicking foreign antigen rescues B cells from peripheral tolerance independent of T cell help, resulting in the accumulation of self-reactive cells in the lymph nodes and secretion of immunoglobulins that bind to a liver-expressed self-antigen. Therefore, our studies reveal a potentially important mechanism by which B lymphocytes can escape self-tolerance.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.