ReviewImmunologic research1999
Eosinophils, ribonucleases and host defense: solving the puzzle.
Review in Immunologic research, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 74 citations in OpenAlex.
- A term infant with severe hypereosinophilia secondary to CMV infection and the STAT1 gene mutation: a case report : List of authors.BMC pediatrics · 2024Article
- Eosinophilic Patterns in Patients with Seasonal Allergy Affected by Bronchial Asthma and Rhinitis/Rhinosinusitis: Efficacy of Benralizumab in Patients with the Persistent Pattern.Journal of clinical medicine · 2024Article
- Eosinophils as potential biomarkers in respiratory viral infections.Frontiers in immunology · 2023Review
- Selective cleavage of ncRNA and antiviral activity by RNase2/EDN in THP1-induced macrophages.Cellular and molecular life sciences : CMLS · 2022Article
- Immunity and Breast Cancer: Focus on Eosinophils.Biomedicines · 2021Review
- "NETs and EETs, a Whole Web of Mess".Microorganisms · 2020Review
- The Eosinophil in Infection.Clinical reviews in allergy & immunology · 2016Review
- Eosinophil-associated ribonuclease 11 is a macrophage chemoattractant.The Journal of biological chemistry · 2015Article
- Antimicrobial activity of high-mobility-group box 2: a new function to a well-known protein.Antimicrobial agents and chemotherapy · 2013Article
- Endobiogeny: a global approach to systems biology (part 2 of 2).Global advances in health and medicine · 2013Review
- Review
- Infection, eosinophilia and childhood asthma.Asia Pacific allergy · 2012Article
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- Article
- Respiratory viruses and eosinophils: exploring the connections.Antiviral research · 2009Review
- RNase A ribonucleases and host defense: an evolving story.Journal of leukocyte biology · 2008Review
- Characterization of the ribonuclease activity on the skin surface.Genetic vaccines and therapy · 2006Article
- A maximum likelihood method for detecting functional divergence at individual codon sites, with application to gene family evolution.Journal of molecular evolution · 2004Article
- Localized eosinophil degranulation mediates disease in tropical pulmonary eosinophilia.Infection and immunity · 2003Article
- Maximum likelihood methods for detecting adaptive evolution after gene duplication.Journal of structural and functional genomics · 2003Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
The eosinophil ribonucleases eosinophil-derived neurotoxin (EDN/RNase 2) and eosinophil cationic protein (ECP/RNase 3) are among the major secretory effector proteins of human eosinophilic leukocytes, cells whose role in host defense remains controversial and poorly understood. We have recently described the unusual manner in which this ribonuclease lineage has evolved, with extraordinary diversification observed in primate as well as in rodent EDNs and ECPs. The results of our evolutionary studies suggest that the EDN/ ECP ribonucleases are in the process of being tailored for a specific, ribonuclease-related goal. With this in mind, we have begun to look carefully at some of the intriguing associations that link eosinophils and their ribonucleases to disease caused by the single-stranded RNA viral pathogen, respiratory syncytial virus (RSV). Recent work in our laboratory has demonstrated that eosinophils can mediate a direct, ribonuclease-dependent reduction in infectivity of RSV in vitro, and that EDN can function alone as an independent antiviral agent. The results of this work have led us to consider the possibility that the EDN/ECP ribonucleases represent a heretofore unrecognized element of innate and specific antiviral host defense.
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Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.