ArticleImmunologic research1999
New gut associated lymphoid tissue "cryptopatches" breed murine intestinal intraepithelial T cell precursors.
Article in Immunologic research, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Perioperative synbiotic treatment to prevent postoperative infectious complications in biliary cancer surgery: a randomized controlled trial.Annals of surgery · 2006Trial
- Fibrinogen and Complement Factor H Induce Parkinsonian and Cognitive Impairment-Like Features in Mice.Cellular and molecular neurobiology · 2025Article
- Evidence for a stepwise program of extrathymic T cell development within the human tonsil.The Journal of clinical investigation · 2012Article
- The human intestinal IgA response; burning questions.Frontiers in immunology · 2012Article
- Distribution, organization and innervation of gastric MALT in conventional piglet.Journal of anatomy · 2011Article
- Identification and characterization of novel gut-associated lymphoid tissues in rat small intestine.Journal of gastroenterology · 2005Article
- Intestinal TSH production is localized in crypt enterocytes and in villus 'hotblocks' and is coupled to IL-7 production: evidence for involvement of TSH during acute enteric virus infection.Immunology letters · 2005Article
- Mucosal immunity and vaccines.Nature medicine · 2005Review
- Surveillance B lymphocytes and mucosal immunoregulation.Springer seminars in immunopathology · 2005Review
- Review
- Influence of the route of infection on development of T-cell receptor beta-chain repertoires of reovirus-specific cytotoxic T lymphocytes.Journal of virology · 2004Article
- Induction of colitis in mice deficient of Peyer's patches and mesenteric lymph nodes is associated with increased disease severity and formation of colonic lymphoid patches.The American journal of pathology · 2002Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Numerous mouse intraepithelial T cells (IEL) bearing either TCR-alphabeta or TCR-gammadelta have been shown to develop somewhere in the intestinal mucosa without passing through the thymus. However, just where these T cells develop has been much less clear and has remained an open question to date. In an effort to investigate this issue, we carried out immunohistochemical study on the murine gastrointestinal tract and identified numerous tiny lymphoid tissues (approximately 1,650 tissues/intestine) in the cryptal region of the small and large intestinal mucosa except for the stomach in which clusters of c-kit+ IL-7R+ Thy1+ lympho-hemopoietic progenitors accumulated (cryptopatches). The cryptopatch cells isolated from the small intestine, which were c-kit positive (c-kit+) but lineage marker negative (Lin-), gave rise to TCR-alphabeta and TCR-gammadelta IELs following in vivo transfer or tissue engraftment into 2 Gy-irradiated severe combined immunodeficient mice. In contrast, cells isolated from Peyer's patches and mesenteric lymph nodes, which belong in the same intestinal immune compartment but lack c-kit+Lin- cells, failed to do so. These results in conjunction with the findings of electron microscopic analysis provide direct evidence of a local intestinal T cell precursor that develops in the cryptopatches.
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Registered trials
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