ArticleAmerican journal of kidney diseases : the official journal of the National Kidney Foundation2000
Cigarette smoking is associated with augmented progression of renal insufficiency in severe essential hypertension.
Article in American journal of kidney diseases : the official journal of the National Kidney Foundation, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed, 151 citations in OpenAlex.
- Urine citrate excretion identifies changes in acid retention as eGFR declines in patients with chronic kidney disease.American journal of physiology. Renal physiology · 2019Trial
- A comparison of treating metabolic acidosis in CKD stage 4 hypertensive kidney disease with fruits and vegetables or sodium bicarbonate.Clinical journal of the American Society of Nephrology : CJASN · 2013Trial
- Baseline predictors of renal disease progression in the African American Study of Hypertension and Kidney Disease.Journal of the American Society of Nephrology : JASN · 2006Trial
- Multisystem Toxicity of E-Cigarettes in Preclinical and Clinical Studies: Pathophysiologic Effects of E-Cigarette Aerosol Exposures from Head to Toe.Annual review of pharmacology and toxicology · 2026Review
- Smoking cessation decreases arterial blood pressure in hypertensive smokers: A subgroup analysis of the randomized controlled trial GENTSMOKING.Tobacco induced diseases · 2024Article
- Association of Opium Addiction with Coronary Artery Ectasia and Coronary Artery Disease.Addiction & health · 2021Article
- Association of smoking with incident CKD risk in the general population: A community-based cohort study.PloS one · 2020Article
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- Prevention and Treatment of Tobacco Use: JACC Health Promotion Series.Journal of the American College of Cardiology · 2018Review
- Selenium nanoparticles with low-level ionizing radiation exposure ameliorate nicotine-induced inflammatory impairment in rat kidney.Environmental science and pollution research international · 2017Article
- Hyperuricemia as a Predictive Marker for Progression of Nephrosclerosis: Clinical Assessment of Prognostic Factors in Biopsy-Proven Arterial/Arteriolar Nephrosclerosis.Journal of atherosclerosis and thrombosis · 2017Article
- Hypoxia: The Force that Drives Chronic Kidney Disease.Clinical medicine & research · 2016Review
- Article
- Religious involvement and health in dialysis patients in Saudi Arabia.Journal of religion and health · 2015Article
- Chronic kidney disease care in the US safety net.Advances in chronic kidney disease · 2015Review
- Nicotine signaling and progression of chronic kidney disease in smokers.Biochemical pharmacology · 2013Review
- Healthy behaviors, risk factor control and awareness of chronic kidney disease.American journal of nephrology · 2013Article
- Cigarette smoking, proteinuria, and renal function in middle-aged Japanese men from an occupational population.Environmental health and preventive medicine · 2012Article
- Prevalence of chronic kidney disease and its association with risk factors in disadvantageous population.International journal of nephrology · 2012Article
- Renal oxidative stress, oxygenation, and hypertension.American journal of physiology. Regulatory, integrative and comparative physiology · 2011Review
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3 authors at 2 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
Hypertension-associated renal disease is a major cause of end-stage renal disease (ESRD) in the United States, but its risk factors remain incompletely defined. Identification and correction of amendable ESRD risk factors among patients with essential hypertension could reduce ESRD prevalence. Patients referred by their primary care physician for hypertension management to an academic nephrology clinic during calendar year 1995 were followed up prospectively. Studied patients had no evidence of secondary hypertension, diabetes, or primary renal disease. All were treated pharmacologically toward a target mean blood pressure (MBP) of 100 mm Hg or less. The course of renal function during follow-up was assessed as the slope of the reciprocal of plasma creatinine concentration (1/P(cr)) plotted against months of follow-up and as the change in calculated glomerular filtration rate (GFR) in milliliters per minute per month. The following patient characteristics were prospectively examined as possible predictive factors for altered renal function: age, sex, ethnicity, initial MBP, initial P(cr) level, initial level of urine protein excretion, and smoking status. Fifty-three patients were enrolled, and follow-up data were available for 51 patients after a mean follow-up of 35.5 months. Despite MBP reduction from 126.8 +/- 1.3 to 96.5 +/- 1.1 mm Hg (P < 0.0001), P(cr) level increased from 1.5 +/- 0.1 to 1.9 +/- 0. 2 mg/dL (P < 0.01). Multivariate regression analysis showed that smoking, greater initial P(cr) level, and black ethnicity were the only examined parameters that independently predicted both a decrease in the 1/P(cr) slope and calculated GFR with at least 95% confidence. Smoking was by far the most powerful of the examined factors, with initial P(cr) and ethnicity being much less predictive. These studies show for the first time that smoking is an independent risk factor for renal function decline in patients with severe essential hypertension.
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