ArticleProtein science : a publication of the Protein Society2000
Folding of beta-sandwich proteins: three-state transition of a fibronectin type III module.
Article in Protein science : a publication of the Protein Society, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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23 citing papers in PubMed, 66 citations in OpenAlex.
- Crystal structure of the Rib domain of the cell-wall-anchored surface protein from Limosilactobacillus reuteri.Acta crystallographica. Section F, Structural biology communications · 2024Article
- Site-specific epitope insertion into recombinant proteins using the MAP tag system.Journal of biochemistry · 2020Article
- Engineering selective competitors for the discrimination of highly conserved protein-protein interaction modules.Nature communications · 2019Article
- PFDB: A standardized protein folding database with temperature correction.Scientific reports · 2019Article
- Computational tools help improve protein stability but with a solubility tradeoff.The Journal of biological chemistry · 2017Article
- Structure and unfolding of the third type III domain from human fibronectin.Biochemistry · 2015Article
- Structural and dynamic properties that govern the stability of an engineered fibronectin type III domain.Protein engineering, design & selection : PEDS · 2015Article
- SLLISWD sequence in the 10FNIII domain initiates fibronectin fibrillogenesis.The Journal of biological chemistry · 2013Article
- Folding intermediate and folding nucleus for I-->N and U-->I-->N transitions in apomyoglobin: contributions by conserved and nonconserved residues.Biophysical journal · 2010Article
- Article
- Transient opening of fibronectin type III (FNIII) domains: the interaction of the third FNIII domain of FN with anastellin.Biochemistry · 2009Article
- Changing the mechanical unfolding pathway of FnIII10 by tuning the pulling strength.Biophysical journal · 2009Article
- Crosstalk between the protein surface and hydrophobic core in a core-swapped fibronectin type III domain.Journal of molecular biology · 2008Article
- Conformational dynamics in loop swap mutants of homologous fibronectin type III domains.Biophysical journal · 2007Article
- Experiments suggest that simulations may overestimate electrostatic contributions to the mechanical stability of a fibronectin type III domain.Journal of molecular biology · 2007Article
- The solution structure of the invasive tip complex from Afa/Dr fibrils.Molecular microbiology · 2006Article
- Structural comparison of the two alternative transition states for folding of TI I27.Biophysical journal · 2006Article
- The folding pathway of a fast-folding immunoglobulin domain revealed by single-molecule mechanical experiments.EMBO reports · 2005Article
- Contact order revisited: influence of protein size on the folding rate.Protein science : a publication of the Protein Society · 2003Article
- High stability of a ferredoxin from the hyperthermophilic archaeon A. ambivalens: involvement of electrostatic interactions and cofactors.Protein science : a publication of the Protein Society · 2001Article
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2 authors at 1 institution in 1 country.
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Abstract
An analysis of the folding of the 94 residue tenth fibronectin type III (fnIII) domain of human fibronectin (FNfn10) is presented. Use of guanidine isothiocyanate as a denaturant allows us to obtain equilibrium and kinetic data across a broad range of denaturant concentrations that are unavailable in guanidine hydrochloride. Equilibrium unfolding experiments show that FNfn10 is significantly more stable than has been reported previously. Comparison of equilibrium and kinetic parameters reveals the presence of an intermediate that accumulates at low denaturant concentrations. This is the first demonstration of three-state folding kinetics for a fnIII domain. We have previously shown that a homologous domain from human tenascin (TNfn3) folds by a two-state mechanism, but this does not necessarily indicate that the two proteins fold by different folding pathways.
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