ArticleProceedings of the National Academy of Sciences of the United States of America2000
Recognition of triple-helical DNA structures by transposon Tn7.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
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Who cites it
26 citing papers in PubMed, 49 citations in OpenAlex.
- Sequential structural rearrangements at the PAM-distal site of a type I-F3 CRISPR-Cas effector enabling RNA-guided DNA transposition.Nucleic acids research · 2026Article
- Asymmetric loading of TnsE regulates Tn7 targeting of DNA replication structures.Nucleic acids research · 2025Article
- Three- and four-stranded nucleic acid structures and their ligands.RSC chemical biology · 2025Review
- Article
- Natural and Engineered Guide RNA-Directed Transposition with CRISPR-Associated Tn7-Like Transposons.Annual review of biochemistry · 2024Review
- Assembly of the Tn7 targeting complex by a regulated stepwise process.Molecular cell · 2024Article
- Modularity and diversity of target selectors in Tn7 transposons.Molecular cell · 2023Article
- Multiple adaptations underly co-option of a CRISPR surveillance complex for RNA-guided DNA transposition.Molecular cell · 2023Article
- Insight into the molecular mechanism of the transposon-encoded type I-F CRISPR-Cas system.Journal, genetic engineering & biotechnology · 2023Review
- Structural basis for DNA targeting by the Tn7 transposon.Nature structural & molecular biology · 2022Article
- Cargo Genes of TnmBio · 2021Article
- Structural basis for target site selection in RNA-guided DNA transposition systems.Science (New York, N.Y.) · 2021Article
- Recruitment of CRISPR-Cas systems by Tn7-like transposons.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Conformational toggling controls target site choice for the heteromeric transposase element Tn7.Nucleic acids research · 2015Article
- The Tn7 transposition regulator TnsC interacts with the transposase subunit TnsB and target selector TnsD.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Architecture of the Tn7 posttransposition complex: an elaborate nucleoprotein structure.Journal of molecular biology · 2010Article
- Characterization of the TnsD-attTn7 complex that promotes site-specific insertion of Tn7.Mobile DNA · 2010Article
- Transposon Tn7 preferentially inserts into GAA*TTC triplet repeats under conditions conducive to Y*R*Y triplex formation.PloS one · 2010Article
- Transposition into replicating DNA occurs through interaction with the processivity factor.Cell · 2009Article
- The chromodomain of Tf1 integrase promotes binding to cDNA and mediates target site selection.Journal of virology · 2009Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
We have found that the bacterial transposon Tn7 can recognize and preferentially insert adjacent to triple-helical nucleic acid structures. Both synthetic intermolecular triplexes, formed through the pairing of a short triplex-forming oligonucleotide on a plasmid DNA, and naturally occurring mirror repeat sequences known to form intramolecular triplexes or H-form DNA are preferential targets for Tn7 insertion in vitro. This target site selectivity depends upon the recognition of the triplex region by a Tn7-encoded ATP-using protein, TnsC, which controls Tn7 target site selection: the interaction of TnsC with the triplex region results in recruitment and activation of the Tn7 transposase. Recognition of a nucleic acid structural motif provides both new information into the factors that influence Tn7's target site selection and broadens its targeting capabilities.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.