ArticleBritish journal of cancer2000
Correlation of metallothionein expression with apoptosis in nasopharyngeal carcinoma.
Article in British journal of cancer, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 52 citations in OpenAlex.
- Article
- Analysis of metallothionein and vimentin immunoreactivity in pharyngeal squamous cell carcinoma and its microenvironment.Cell and tissue research · 2013Article
- Identification of heat shock protein 27 as a radioresistance-related protein in nasopharyngeal carcinoma cells.Journal of cancer research and clinical oncology · 2012Article
- The Potential Role of MT and Vimentin Immunoreactivity in the Remodeling of the Microenvironment of Parotid Adenocarcinoma.Cancer microenvironment : official journal of the International Cancer Microenvironment Society · 2010Article
- Metallothionein as an anti-inflammatory mediator.Mediators of inflammation · 2009Review
- Metallothionein: an overview.World journal of gastroenterology · 2007Review
- Clinicopathological significance of metallothioneins in breast cancer.Pathology oncology research : POR · 2004Review
- Differential expression of metallothionein 1 and 2 isoforms in breast cancer lines with different invasive potential: identification of a novel nonsilent metallothionein-1H mutant variant.The American journal of pathology · 2003Article
- Using yeast two-hybrid system to identify ECRG2 associated proteins and their possible interactions with ECRG2 gene.World journal of gastroenterology · 2003Article
- Metallothionein expression in hepatocellular carcinoma.World journal of gastroenterology · 2002Article
- Metallothionein 1E mRNA is highly expressed in oestrogen receptor-negative human invasive ductal breast cancer.British journal of cancer · 2000Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The expression of metallothionein (MT), an intracellular ubiquitous low molecular weight protein thiol with antioxidant properties, was studied in nasopharyngeal cancer (NPC) and correlated with the apoptotic index. Immunohistochemical staining of randomly selected, formalin-fixed and paraffin-embedded normal and malignant nasopharyngeal tissues were analysed for the expression of MT using the commercially available E9 antibody directed against MT I and MT II isoforms. The corresponding apoptosis labelling indices were evaluated by the TUNEL method. Localization of MT at the ultrastructural level was studied by immunogold labelling. All the tumour sections (17 specimens) showed MT-immunopositivity. A direct correlation between the percentage of MT-positive cells and the staining intensity was noted (P < 0.001; Pearson's r = 0.95). There was absence of cytoplasmic staining and only nuclear staining (with localization in the nucleoplasm) was demonstrated in the tumour cells. In normal epithelium of the nasopharynx, the basal layer was stained. An inverse relationship was observed between the level of MT expression and the apoptotic index in the NPC tissues (P = 0.0059; Pearson's r = -0.6380). The results suggest that overexpression of MT in NPC may protect the tumour cells from entering into the apoptotic process and thereby contribute to tumour expansion. Preferential localization of MT in the nuclei of NPC cells may possibly enhance radioresistance since radiotherapy is known to eradicate tumour cells by free radical-induced apoptosis.
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