ArticleGenes & development2000
The zinc ribbon domains of the general transcription factors TFIIB and Brf: conserved functional surfaces but different roles in transcription initiation.
Article in Genes & development, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed.
- The interactome of the Bakers' yeast peroxiredoxin Tsa1 implicates it in redox regulation of intermediary metabolism, glycolysis, and zinc homeostasis.Metallomics : integrated biometal science · 2025Article
- Guided tour through the small protein landscape ofmicroLife · 2025Article
- Chemoproteomic Profiling Maps Zinc-Dependent Cysteine Reactivity.Chemical research in toxicology · 2024Article
- Genome-wide association study (GWAS) with high-throughput SNP chip DNA markers identified novel genetic factors for mesocotyl elongation and seedling emergence in rice (Frontiers in genetics · 2023Article
- Restriction of Flaviviruses by an Interferon-Stimulated Gene SHFL/C19orf66.International journal of molecular sciences · 2022Review
- CRISPR sequences are sometimes erroneously translated and can contaminate public databases with spurious proteins containing spaced repeats.Database : the journal of biological databases and curation · 2020Article
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- BRF1 mutations in a family with growth failure, markedly delayed bone age, and central nervous system anomalies.Clinical genetics · 2017Article
- Structural basis for suppression of hypernegative DNA supercoiling by E. coli topoisomerase I.Nucleic acids research · 2015Article
- A Region of Bdp1 Necessary for Transcription Initiation That Is Located within the RNA Polymerase III Active Site Cleft.Molecular and cellular biology · 2015Article
- BRF1 mutations alter RNA polymerase III-dependent transcription and cause neurodevelopmental anomalies.Genome research · 2015Article
- Architecture of the Saccharomyces cerevisiae RNA polymerase I Core Factor complex.Nature structural & molecular biology · 2014Article
- Mapping the protein interaction network for TFIIB-related factor Brf1 in the RNA polymerase III preinitiation complex.Molecular and cellular biology · 2014Article
- The σ enigma: bacterial σ factors, archaeal TFB and eukaryotic TFIIB are homologs.Transcription · 2014Article
- TAF1B is a TFIIB-like component of the basal transcription machinery for RNA polymerase I.Science (New York, N.Y.) · 2011Article
- The TFIIF-like Rpc37/53 dimer lies at the center of a protein network to connect TFIIIC, Bdp1, and the RNA polymerase III active center.Molecular and cellular biology · 2011Article
- A TFIIB-like protein is indispensable for spliced leader RNA gene transcription in Trypanosoma brucei.Nucleic acids research · 2006Article
- Structure-function analysis of the human TFIIB-related factor II protein reveals an essential role for the C-terminal domain in RNA polymerase III transcription.Molecular and cellular biology · 2005Article
- Structure and mechanism of the RNA polymerase II transcription machinery.Nature structural & molecular biology · 2004Review
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Authors and funding
2 authors.
Funding
Abstract
The function of the conserved zinc-binding domains in the related Pol II- and Pol III-specific factors TFIIB and Brf was investigated. Three-dimensional structure modeling and mutagenesis studies indicated that for both factors, the functional surface of the zinc ribbon fold consists of a small conserved patch of residues located on one face of the domain comprised mainly of the second and third antiparallel beta strands. Previous studies have shown that the TFIIB zinc ribbon is essential for recruitment of Pol II into the preinitiation complex. In contrast, Pol III recruitment assays and in vitro transcription demonstrate that the disruption of the Brf zinc ribbon does not lead to a defect in Pol III recruitment but, rather, a defect in open complex formation. Therefore, the same conserved surface of the zinc ribbon domain has been adapted to serve distinct roles in the Pol II and Pol III transcription machinery.
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10733531PMC316465What OpenQuestion holds
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