ArticleBritish journal of cancer2000
In vitro modelling of epithelial and stromal interactions in non-malignant and malignant prostates.
Article in British journal of cancer, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
24 citing papers in PubMed, 52 citations in OpenAlex.
- Stromal AR inhibits prostate tumor progression by restraining secretory luminal epithelial cells.Cell reports · 2022Article
- Recent Advances in Cancer Plasticity: Cellular Mechanisms, Surveillance Strategies, and Therapeutic Optimization.Frontiers in oncology · 2020Review
- CXCL1-LCN2 paracrine axis promotes progression of prostate cancer via the Src activation and epithelial-mesenchymal transition.Cell communication and signaling : CCS · 2019Article
- Myofibroblast androgen receptor expression determines cell survival in co-cultures of myofibroblasts and prostate cancer cellsOncotarget · 2018Article
- Hypoxia on the Expression of Hepatoma Upregulated Protein in Prostate Cancer Cells.Frontiers in oncology · 2016Article
- Effects of oxygen on the antigenic landscape of prostate cancer cells.BMC research notes · 2015Article
- Nuclear targeting of dystroglycan promotes the expression of androgen regulated transcription factors in prostate cancer.Scientific reports · 2013Article
- Article
- The differential effects of prostate stromal cells derived from different zones on prostate cancer epithelial cells under the action of sex hormones.Asian journal of andrology · 2011Article
- [From tumor tissue via primary cultures to xenograft models: a functional approach in prostate cancer research].Der Urologe. Ausg. A · 2011Article
- Stroma regulates increased epithelial lateral cell adhesion in 3D culture: a role for actin/cadherin dynamics.PloS one · 2011Article
- GLI1 confers profound phenotypic changes upon LNCaP prostate cancer cells that include the acquisition of a hormone independent state.PloS one · 2011Article
- Human prostate sphere-forming cells represent a subset of basal epithelial cells capable of glandular regeneration in vivo.The Prostate · 2010Article
- Decrease in stromal androgen receptor associates with androgen-independent disease and promotes prostate cancer cell proliferation and invasion.Journal of cellular and molecular medicine · 2008Article
- Isoforms of endothelin-converting enzyme-1 (ECE-1) have opposing effects on prostate cancer cell invasion.British journal of cancer · 2008Article
- Bone marrow stromal cells enhance prostate cancer cell invasion through type I collagen in an MMP-12 dependent manner.International journal of cancer · 2008Article
- Host matrix metalloproteinase-9 contributes to tumor vascularization without affecting tumor growth in a model of prostate cancer bone metastasis.Clinical & experimental metastasis · 2006Article
- The use of Raman spectroscopy to differentiate between different prostatic adenocarcinoma cell lines.British journal of cancer · 2005Article
- Citrate transport in the human prostate epithelial PNT2-C2 cell line: electrophysiological analyses.The Journal of physiology · 2004Article
- Stromal-epithelial interactions influence prostate cancer cell invasion by altering the balance of metallopeptidase expression.British journal of cancer · 2004Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To study the effects of stromal epithelial cell interactions on prostate cancer metastasis, we have used primary human prostatic stromal cells derived from malignant and non-malignant tissues and established epithelial cell lines from normal (PNT1a and PNT2-C2) and tumour (PC-3, DU145 and LNCaP) origins. The effects of stromal cells on epithelial cell growth were studied in direct and indirect (using culture inserts) co-culture and by exposure to stromal cell-conditioned medium (assessed by MTT assay). The influence of stromal cells on epithelial cell invasion was measured using matrigel invasion chambers and on epithelial cell motility using time lapse microscopy. Results indicated that epithelial cell line growth was similarly unaffected or inhibited by stromal cells derived from malignant (n = 8) or non-malignant tissue (n = 8). In contrast, PNT2-C2 and PC-3 cells were found to be the least and the most invasive and motile epithelia respectively. Stromal cultures enhanced the invasion of both epithelial cells, but no differences were observed between the use of malignant and non-malignant tissues. All stromal cultures modestly stimulated PNT2-C2 motility but displayed a greater stimulation of PC-3 cell motility, while stromal cells derived from malignant tissue stimulated PNT2-C2 and PC-3 cell motility more than stromal cultures from non-malignant tissues.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.