ArticleBritish journal of cancer2000
Selective initial in vivo homing pattern of 5T2 multiple myeloma cells in the C57BL/KalwRij mouse.
Article in British journal of cancer, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 0 citations in OpenAlex.
- Adhesion molecules in multiple myeloma oncogenesis and targeted therapy.International journal of hematologic oncology · 2022Review
- Desmoglein-2 expression is an independent predictor of poor prognosis patients with multiple myeloma.Molecular oncology · 2022Article
- Tumour Dissemination in Multiple Myeloma Disease Progression and Relapse: A Potential Therapeutic Target in High-Risk Myeloma.Cancers · 2020Review
- Bone marker gene expression in calvarial bones: different bone microenvironments.Journal of biological research (Thessalonike, Greece) · 2017Article
- Bone metastasis: the importance of the neighbourhood.Nature reviews. Cancer · 2016Review
- [(89)Zr]oxinate4 for long-term in vivo cell tracking by positron emission tomography.European journal of nuclear medicine and molecular imaging · 2015Article
- Article
- A novel mouse model for multiple myeloma (MOPC315.BM) that allows noninvasive spatiotemporal detection of osteolytic disease.PloS one · 2012Article
- Tumorigenic potential and disease manifestations of malignant B-cell variants differing in their fibronectin adhesiveness.Experimental hematology · 2008Article
- Extravasation and homing mechanisms in multiple myeloma.Clinical & experimental metastasis · 2008Review
- Neighboring adipocytes participate in the bone marrow microenvironment of multiple myeloma cells.Leukemia · 2007Article
- Bone marrow angiogenesis in multiple myeloma.Leukemia · 2006Review
- Role of CCR1 and CCR5 in homing and growth of multiple myeloma and in the development of osteolytic lesions: a study in the 5TMM model.Clinical & experimental metastasis · 2006Article
- Multifunctional role of matrix metalloproteinases in multiple myeloma: a study in the 5T2MM mouse model.The American journal of pathology · 2004Article
- Article
- Specific roles for the PI3K and the MEK-ERK pathway in IGF-1-stimulated chemotaxis, VEGF secretion and proliferation of multiple myeloma cells: study in the 5T33MM model.British journal of cancer · 2004Article
- Chemokine receptor CCR2 is expressed by human multiple myeloma cells and mediates migration to bone marrow stromal cell-produced monocyte chemotactic proteins MCP-1, -2 and -3.British journal of cancer · 2003Article
- The new anti-actin agent dihydrohalichondramide reveals fenestrae-forming centers in hepatic endothelial cells.BMC cell biology · 2002Article
- Mechanisms involved in the differential bone marrow homing of CD45 subsets in 5T murine models of myeloma.Clinical & experimental metastasis · 2002Article
- Monocyte chemoattractant protein-1 (MCP-1), secreted by bone marrow endothelial cells, induces chemoattraction of 5T multiple myeloma cells.Clinical & experimental metastasis · 2002Article
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
One of the main characteristics of multiple myeloma cells is their predominant localization in the bone marrow. It is, however, unclear whether this is due to a selective initial entry, or whether this entry is more random and other processes like survival and/or growth stimulation, only present in the medullar microenvironment, are unique. To investigate this, in vivo homing kinetics of murine 5T2MM cells shortly after injection were assessed in bone marrow, liver, spleen, lungs, heart, intestines, kidney and testis by tracing of radiolabelled cells, by immunostaining of isolated cells and by polymerase chain reaction analysis. We demonstrated the presence of 5T2MM cells in bone marrow, spleen and liver with all other organs being negative. Adhesion assays of 5T2MM cells to different types of endothelial cells demonstrated a selective adhesion of 5T2MM cells to bone marrow and liver and not to lung endothelial cells. We here demonstrate that the specific in vivo localization of the 5T2MM cells is a result of the combination of a selective entry/adhesion of the 5T2MM cells in the bone marrow, spleen and liver, and a selective survival and growth of these tumour cells in the bone marrow and spleen but not in the liver.
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