ArticleBritish journal of cancer2000
Association of CYP1A1 and microsomal epoxide hydrolase polymorphisms with lung squamous cell carcinoma.
Article in British journal of cancer, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 59 citations in OpenAlex.
- The Association between EPHX1 Gene Polymorphisms and Lung Cancer among Jordanian People.Asian Pacific journal of cancer prevention : APJCP · 2024Article
- Polymorphisms of CYP1A1 and GSTM1 genes and susceptibility to oral cancer.Yonsei medical journal · 2007Article
- Genetic analysis of microsomal epoxide hydrolase gene and its association with lung cancer risk.European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP) · 2005Article
- GSTM1, GSTT1, GSTP1 and CYP1A1 genetic polymorphisms and susceptibility to esophageal cancer in a French population: different pattern of squamous cell carcinoma and adenocarcinoma.World journal of gastroenterology · 2004Article
- Functional analysis of human microsomal epoxide hydrolase genetic variants.Chemico-biological interactions · 2004Article
- Genetic polymorphism of the CYP1A1, CYP2E1, GSTM1 and GSTT1 genes and lung cancer susceptibility in a north indian population.Molecular and cellular biochemistry · 2004Article
- Genetic susceptibility to tobacco-related cancer.Oncogene · 2004Review
- Association of microsomal epoxide hydrolase polymorphisms and lung cancer risk.British journal of cancer · 2003Article
- Epoxide hydrolase genotype and orolaryngeal cancer risk: interaction with GSTM1 genotype.Oral oncology · 2003Article
- Association of GSTM1, CYP1A1 and CYP2E1 genetic polymorphisms with susceptibility to lung adenocarcinoma: a case-control study in Chinese population.Cancer science · 2003Article
- Genetic polymorphism of enzymes involved in xenobiotic metabolism and the risk of lung cancer.Environmental health and preventive medicine · 2002Article
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Authors and funding
8 authors at 4 institutions in 1 country.
Funding
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Abstract
Lung cancer is the leading cause of death among cancers in Taiwan. Although the etiology of lung cancer has yet to be defined, genetic variability in activities of metabolic enzymes has been correlated with lung cancer. In the present study, the possibility of association of CYP1A1 and microsomal epoxide hydrolase (HYL1) genetic polymorphisms with lung cancer was examined among 132 lung cancer patients and 259 controls in Taiwan. No significant association was observed for either CYP1A1 or HYL1 polymorphism alone and the overall incidence of lung cancer after adjusting for age, gender and smoking status. When cases were stratified according to histological type, there was significant association between CYP1A1*2A homozygote and squamous cell carcinoma (SCC) (odds ratio (OR) 2.86; 95% confidence interval (CI) 1.33-6.12). Similarly, the proportion of HYL1 genotypes corresponding to high or normal enzyme activities was higher in SCC than in controls (OR 1.96; 95% CI 1.04-3.70). A combination of susceptible CYP1A1 and HYL1 genotypes was found to be highly associated with lung cancer, especially with SCC (OR 6.76; 95% CI 2.29-19.10). Our results suggest that the combination of CYP1A1 and HYL1 polymorphisms is an important risk factor for lung SCC.
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