Evidence map›Paper›PMID 10731173›Full record

Trial reportBMJ (Clinical research ed.)2000

Immediate and long term effects of weight reduction in obese people with asthma: randomised controlled study.

B Stenius-Aarniala, T Poussa, J Kvarnström, E L Grönlund, M Ylikahri, P Mustajoki

Erratum issuedAbstract readClinical TrialRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in BMJ (Clinical research ed.), 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 147 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
147citing papers in PubMed, 7 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

147 citing papers in PubMed, 7 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Guideline
  4. Psychosocial factors and behavioral medicine interventions in asthma.Journal of consulting and clinical psychology · 2013
    Pooled it
  5. Weight loss interventions for chronic asthma.The Cochrane database of systematic reviews · 2012
    Pooled it
  6. Calorie controlled diet for chronic asthma.The Cochrane database of systematic reviews · 2005
    Pooled it
  7. Guideline
  8. Trial
  9. An Online Weight Loss Intervention for People With Obesity and Poorly Controlled Asthma.The journal of allergy and clinical immunology. In practice · 2022
    Trial
  10. Trial
  11. The added effect of comorbidity on health-related quality of life in patients with asthma.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2015
    Trial
  12. Trial
  13. Trial
  14. Trial
  15. Trial
  16. Trial
  17. Trial
  18. Airway Obstruction Worsens in Young Adults with Asthma Who Become Obese.The journal of allergy and clinical immunology. In practice
    Trial
  19. Article
  20. Review

87 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

B Stenius-AarnialaDivision of Pulmonary Medicine and Allergology, Helsinki University Central Hospital, FIN-00029 HYKS, Helsinki, Finland. bstenius@cc.helsinki.fi
T Poussa
J Kvarnström
E L Grönlund
M Ylikahri
P Mustajoki

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo investigate the influence of weight reduction on obese patients with asthma.

designOpen study, two randomised parallel groups.

settingPrivate outpatients centre, Helsinki, Finland.

participantsTwo groups of 19 obese patients with asthma (body mass index (kg/m(2)) 30 to 42) recruited through newspaper advertisements.

interventionSupervised weight reduction programme including 8 week very low energy diet.

main outcome measuresBody weight, morning peak expiratory flow (PEF), forced vital capacity (FVC), forced expiratory volume in one second (FEV(1)); and also asthma symptoms, number of acute episodes, courses of oral steroids, health status (quality of life).

resultsAt the end of the weight reducing programme, the participants in the treatment group had lost a mean of 14.5% of their pretreatment weight, the controls 0.3%. The corresponding figures after one year were 11.3% and a weight gain of 2.2%. After the 8 week dieting period the difference in changes in percentage of predicted FEV(1) from baseline in the treatment and control groups was 7.2% (95% confidence interval 1.9% to 12.5%, P=0. 009). The corresponding difference in the changes in FVC was 8.6% (4. 8% to 12.5%, P<0.0001). After one year the differences in the changes in the two groups were still significant: 7.6% for FEV(1) (1. 5% to 13.8%, P=0.02) and 7.6% for FVC (3.5% to 11.8%, P=0.001). By the end of the weight reduction programme, reduction in dyspnoea was 13 mm (on a visual analogue scale 0 mm to 100 mm) in the treatment group and 1 mm in the control group (P=0.02). The reduction of rescue medication was 1.2 and 0.1 doses respectively (P=0.03). After one year the differences in the changes between the two groups were -12 for symptom scores (range -1 to -22, P=0.04) and -10 for total scores (-18 to -1, P=0.02). The median number of exacerbations in the treatment group was 1 (0-4) and in the controls 4 (0-7), P=0.001.

conclusionWeight reduction in obese patients with asthma improves lung function, symptoms, morbidity, and health status.

Indexed as

Weight LossAdultAnalysis of VarianceAsthmaConfidence IntervalsDiet, ReducingHumansMiddle AgedObesityPeak Expiratory Flow RateStatistics, NonparametricTime Factors

Identifiers

PMID10731173
PMCPMC27319

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.