ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2000
Progressive postnatal assembly of limbic-autonomic circuits revealed by central transneuronal transport of pseudorabies virus.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers.
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Who cites it
50 citing papers in PubMed.
- Anatomy and function of efferent and afferent vagal innervation of the stomach.Autonomic neuroscience : basic & clinical · 2026Review
- Experience-dependent development of vagal circuitry in rodents and humans.Neuroscience and biobehavioral reviews · 2026Review
- Transsynaptic viral tools in neural circuit analysis: from anatomical mapping to functional interrogation.Frontiers in neural circuits · 2026Review
- CNS sites controlling the gastric pyloric sphincter: Neuroanatomical and functional study in the rat.The Journal of comparative neurology · 2023Article
- Perinatal high-fat diet exposure alters oxytocin and corticotropin releasing factor inputs onto vagal neurocircuits controlling gastric motility.The Journal of physiology · 2023Article
- Lasting impact of postnatal maternal separation on the developing BNST: Lifelong socioemotional consequences.Neuropharmacology · 2023Review
- Resilience to Stress: Lessons from Rodents about Nature versus Nurture.The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry · 2022Review
- Opposing relationships of childhood threat and deprivation with stria terminalis white matter.Human brain mapping · 2021Article
- Interactions between childhood maltreatment and combat exposure trauma on stress-related activity within the cingulate cortex: a pilot study.Military psychology : the official journal of the Division of Military Psychology, American Psychological Association · 2020Article
- The center of olfactory bulb-seeded α-synucleinopathy is the limbic system and the ensuing pathology is higher in male than in female mice.Brain pathology (Zurich, Switzerland) · 2019Article
- Research domain criteria and the study of trauma in children: Implications for assessment and treatment research.Clinical psychology review · 2018Review
- Connectivity between the central nucleus of the amygdala and the bed nucleus of the stria terminalis in the non-human primate: neuronal tract tracing and developmental neuroimaging studies.Brain structure & function · 2017Article
- Developmental regulation of inhibitory synaptic currents in the dorsal motor nucleus of the vagus in the rat.Journal of neurophysiology · 2016Article
- Inhibitory neurotransmission regulates vagal efferent activity and gastric motility.Experimental biology and medicine (Maywood, N.J.) · 2016Review
- Childhood maltreatment is associated with altered frontolimbic neurobiological activity during wakefulness in adulthood.Development and psychopathology · 2016Article
- High fat diet attenuates glucose-dependent facilitation of 5-HT3 -mediated responses in rat gastric vagal afferents.The Journal of physiology · 2016Article
- Developmental specification of metabolic circuitry.Frontiers in neuroendocrinology · 2015Review
- Childhood physical abuse predicts stressor-evoked activity within central visceral control regions.Social cognitive and affective neuroscience · 2015Article
- Gene-environment interactions controlling energy and glucose homeostasis and the developmental origins of obesity.Physiological reviews · 2015Review
- Exposure to a high fat diet during the perinatal period alters vagal motoneurone excitability, even in the absence of obesity.The Journal of physiology · 2015Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
The development of neuronal projections to a target and the establishment of synaptic connections with that target can be temporally distinct events, which typically are distinguished by functional assessments. We have applied a novel neuroanatomical approach to characterize the development of limbic forebrain synaptic inputs to autonomic neurons in neonatal rats. Transneuronal labeling of preautonomic forebrain neurons was achieved by inoculating the ventral stomach wall with pseudorabies virus (PRV) on postnatal day 1 (P1), P4, or P8. In each age group, PRV-positive neurons were present in autonomic and preautonomic regions of the spinal cord and brainstem 62-64 hr after inoculation. Transneuronal forebrain labeling in rats injected on P8 was similar to the transneuronal labeling reported previously in adult rats and included neurons in the medial and lateral hypothalamus, amygdala, bed nucleus of the stria terminalis, and visceral cortices. However, no cortex labeling and only modest amygdala and bed nucleus labeling were observed in rats injected with PRV on P4, and only medial hypothalamic labeling was observed in rats injected on P1. Additional tracing experiments involving central injections of PRV or cholera toxin beta indicated that lateral hypothalamic and telencephalic regions projected to the medullary dorsal vagal complex several days before establishing synaptic connections with gastric-related autonomic neurons. These results demonstrate a novel strategy for evaluating synaptic connectivity in developing neural circuits and show a temporally segregated postnatal emergence of medial hypothalamic, lateral hypothalamic, and telencephalic synaptic inputs to central autonomic neurons.
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Identifiers
10729354PMC6772232What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.