ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2000
Emx2 is required for growth of the hippocampus but not for hippocampal field specification.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- A developmental gradient of COUP-TFI expression regulates the relative size of hippocampus dorsal and ventral subregions.PLoS biology · 2025Article
- Novel Insights into Emx2 and Dmrta2 Cooperation during Cortex Development and Evidence for Dmrta2 Function in the Choroid Plexus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Emx2 is an essential regulator of ciliated cell development across embryonic tissues.iScience · 2024Article
- Article
- Regulation of sarcomagenesis by the empty spiracles homeobox genes EMX1 and EMX2.Cell death & disease · 2021Article
- Hippocampal Malrotation: A Genetic Developmental Anomaly Related to Epilepsy?Brain sciences · 2021Review
- Redistribution of EZH2 promotes malignant phenotypes by rewiring developmental programmes.EMBO reports · 2019Article
- DMRT5, DMRT3, and EMX2 Cooperatively RepressThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- Forced Expression of Foxg1 in the Cortical Hem Leads to the Transformation of Cajal-Retzius Cells into Dentate Granule Neurons.Journal of developmental biology · 2018Article
- DMRT5 Together with DMRT3 Directly Controls Hippocampus Development and Neocortical Area Map Formation.Cerebral cortex (New York, N.Y. : 1991) · 2018Article
- The downregulation of lncRNA EMX2OS might independently predict shorter recurrence-free survival of classical papillary thyroid cancer.PloS one · 2018Article
- Transcription factor Emx2 controls stereociliary bundle orientation of sensory hair cells.eLife · 2017Article
- Akirin2 is essential for the formation of the cerebral cortex.Neural development · 2016Article
- The cortical hem regulates the size and patterning of neocortex.Development (Cambridge, England) · 2014Article
- The doublesex homolog Dmrt5 is required for the development of the caudomedial cerebral cortex in mammals.Cerebral cortex (New York, N.Y. : 1991) · 2013Article
- Emx3 is required for the differentiation of dorsal telencephalic neurons.Developmental dynamics : an official publication of the American Association of Anatomists · 2009Article
- Specific glial populations regulate hippocampal morphogenesis.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2008Article
- Central roles of the roof plate in telencephalic development and holoprosencephaly.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2006Article
- Emx2 and Pax6 function in cooperation with Otx2 and Otx1 to develop caudal forebrain primordium that includes future archipallium.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2005Article
- Selective requirement of Pax6, but not Emx2, in the specification and development of several nuclei of the amygdaloid complex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2005Article
Corrections and comments
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Authors and funding
4 authors.
Funding
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Abstract
The vertebrate Emx genes are expressed in a nested pattern in early embryonic cerebral cortex, such that a medial strip of cortex expresses Emx2 but not Emx1. This pattern suggests that Emx genes could play a role in specifying different areas or fields of the cortex along the mediolateral axis. Such a role has been supported by the observation that in mice lacking functional Emx2 the hippocampus is shrunken and the most medial field of the cortex, the hippocampal dentate gyrus, appears by cytoarchitecture to be missing (Pellegrini et al., 1996; Yoshida et al., 1997). Use of region-specific molecular markers shows, however, that hippocampal fields are specified and correctly positioned in the Emx2 mutant. In particular, a dentate cell population is generated, although it fails to form a morphological gyrus. This failure may be part of a more widespread medial cortical defect in the mutant. Examination of cortical cell proliferation and differentiation indicates a disruption of the maturation of the medial cortex in the absence of Emx2. Thus, Emx2 is required for normal growth and maturation of the hippocampus but not for the specification of cells to particular hippocampal field identities.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.