ArticleJournal of virology2000
Synaptic pathology in Borna disease virus persistent infection.
Article in Journal of virology, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
What it found
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Who cites it
31 citing papers in PubMed.
- Viral modulation of synaptic pruning: implications for neuropathology and brain function.Journal of virology · 2026Review
- Virus-Host Protein Interaction Network of the Hepatitis E Virus ORF2-4 by Mammalian Two-Hybrid Assays.Viruses · 2023Article
- Word recognition memory and serum levels of Borna disease virus specific circulating immune complexes in obsessive-compulsive disorder.BMC psychiatry · 2022Article
- Nucleoprotein (P40) Binding to 5HT2C Receptors (5HT2CR) is the Key Point in the Pathogenesis of BoDV-1-Infected Hosts.Neurochemical research · 2021Article
- Zika virus replicates in adult human brain tissue and impairs synapses and memory in mice.Nature communications · 2019Article
- Central Nervous System Infection with Borna Disease Virus Causes Kynurenine Pathway Dysregulation and Neurotoxic Quinolinic Acid Production.Journal of virology · 2017Article
- Borna disease virus phosphoprotein impairs the developmental program controlling neurogenesis and reduces human GABAergic neurogenesis.PLoS pathogens · 2015Article
- A synthetic cannabinoid agonist promotes oligodendrogliogenesis during viral encephalitis in rats.Experimental neurology · 2010Article
- Inflammation in neuroviral diseases.Journal of neural transmission (Vienna, Austria : 1996) · 2010Article
- Animal models of CNS viral disease: examples from borna disease virus models.Interdisciplinary perspectives on infectious diseases · 2010Article
- Borna disease virus P protein affects neural transmission through interactions with gamma-aminobutyric acid receptor-associated protein.Journal of virology · 2008Article
- Proteomic analysis reveals selective impediment of neuronal remodeling upon Borna disease virus infection.Journal of virology · 2008Article
- Astrocytes play a key role in activation of microglia by persistent Borna disease virus infection.Journal of neuroinflammation · 2008Article
- Persistent Borna Disease Virus (BDV) infection activates microglia prior to a detectable loss of granule cells in the hippocampus.Journal of neuroinflammation · 2008Article
- Cannabinoid rescue of striatal progenitor cells in chronic Borna disease viral encephalitis in rats.Journal of neurovirology · 2008Article
- Borna disease virus RNA detected in Japanese macaques (Macaca fuscata).Primates; journal of primatology · 2008Article
- Axonal degeneration as a self-destructive defense mechanism against neurotropic virus infection.Future virology · 2008Article
- Borna disease virus infection impairs synaptic plasticity.Journal of virology · 2007Article
- Neonatal Borna disease virus infection in rats is associated with increased extracellular levels of glutamate and neurodegeneration in the striatum.Journal of neurovirology · 2007Article
- Reverse-genetic approaches to the study of Borna disease virus.Nature reviews. Microbiology · 2006Review
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Borna disease virus (BDV) infection of newborn rats leads to a persistent infection of the brain, which is associated with behavioral and neuroanatonomical abnormalities. These disorders occur in the absence of lymphoid cell infiltrates, and BDV-induced cell damage is restricted to defined brain areas. To investigate if damage to synaptic structures anteceded neuronal loss in BDV neonatally infected rats, we analyzed at different times postinfection the expression levels of growth-associated protein 43 and synaptophysin, two molecules involved in neuroplasticity processes. We found that BDV induced a progressive and marked decrease in the expression of these synaptic markers, which was followed by a significant loss of cortical neurons. Our findings suggest that BDV persistent infection interferes with neuroplasticity processes in specific cell populations. This, in turn, could affect the proper supply of growth factors and other molecules required for survival of selective neuronal populations within the cortex and limbic system structures.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.