ArticleJournal of thrombosis and thrombolysis2000
Circulating levels of IL-1beta, a prothrombotic cytokine, are elevated in unstable angina versus stable angina.
Article in Journal of thrombosis and thrombolysis, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 53 citations in OpenAlex.
- Cardiovascular evaluation and endothelial dysfunction in Cushing syndrome following remission: a prospective study.Journal of endocrinological investigation · 2024Article
- IL1α Antagonizes IL1β and Promotes Adaptive Immune Rejection of Malignant Tumors.Cancer immunology research · 2020Article
- Postmortem plasma pentraxin 3 is a useful marker of fatal acute coronary syndrome.Scientific reports · 2019Article
- Consolidated and emerging inflammatory markers in coronary artery disease.World journal of experimental medicine · 2015Review
- Network analysis of inflammatory genes and their transcriptional regulators in coronary artery disease.PloS one · 2014Article
- Genetic dissection of the pre-eclampsia susceptibility locus on chromosome 2q22 reveals shared novel risk factors for cardiovascular disease.Molecular human reproduction · 2013Article
- A Systems Biology Approach to Characterize Biomarkers for Blood Stasis Syndrome of Unstable Angina Patients by Integrating MicroRNA and Messenger RNA Expression Profiling.Evidence-based complementary and alternative medicine : eCAM · 2013Article
- Subacute inflammatory activation in subjects with acute coronary syndrome and left ventricular dysfunction.Inflammation · 2012Article
- Inflammatory cytokines imbalance in the very early phase of acute coronary syndrome: correlations with angiographic findings and in-hospital events.Inflammation · 2011Article
- Cardiac release and kinetics of cytokines after elective bare metal coronary stenting.Journal of thrombosis and thrombolysis · 2010Article
- Correlation between interleukin 6 and interleukin 10 in acute myocardial infarction.Bosnian journal of basic medical sciences · 2009Article
- Psychobiology of depression/distress in congestive heart failure.Heart failure reviews · 2009Review
- IL1B genetic variation and plasma C-reactive protein level among young adults: the CARDIA study.Atherosclerosis · 2009Article
- VASCULAR INFLAMMATION AND ATHEROGENESIS ARE ACTIVATED VIA RECEPTORS FOR PAMPs AND SUPPRESSED BY REGULATORY T CELLS.Drug discovery today. Therapeutic strategies · 2008Article
- Relation between proinflammatory to anti-inflammatory cytokine ratios and long-term prognosis in patients with non-ST elevation acute coronary syndrome.Heart (British Cardiac Society) · 2006Article
- Serial changes in plasma levels of cytokines in patients with coronary artery disease.Vascular health and risk management · 2005Article
- Levels of serum IL-1beta, IL-2, IL-8 and tumor necrosis factor-alpha in patients with unstable angina pectoris.Mediators of inflammation · 2003Article
- Interleukin-6 and acute coronary syndrome.Clinical cardiology · 2001Article
- Relationship between site of myocardial infarction, left ventricular function and cytokine levels in patients undergoing coronary artery surgery.Cardiovascular journal of AfricaArticle
- Biomarkers to monitor the prognosis, disease severity, and treatment efficacy in coronary artery disease.Expert review of cardiovascular therapyReview
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMultiple studies support a role for inflammation in the pathogenesis of coronary atherosclerosis and unstable cardiac syndromes. However, of the known proinflammatory cytokines, only elevated plasma levels of interleukin-6 have been linked to unstable angina. We sought to examine the plasma levels of other major proinflammatory cytokines in similar clinical settings and to determine the extent of the relationship between inflammation and unstable coronary syndromes by measuring the levels of various proinflammatory cytokines in patients with stable and unstable angina.
methodsWe measured plasma levels of interleukin-1 beta (IL-1beta), tumor necrosis factor alpha (TNF-alpha), and interleukin 6 (IL-6) in 97 patients: 67 with stable angina, 24 with unstable angina, and 15 healthy controls.
resultsMean levels of IL-1beta were significantly higher in patients with unstable angina as compared to patients with stable angina (p =.009). Levels of IL-6 were significantly higher than control patients for both stable angina and unstable angina patients (p =.031 and.006, respectively). No significant differences were found in the levels of TNF-alpha.
conclusionsOur results suggest that both IL-1beta and IL-6 contribute to the pathogenesis of unstable angina, and that the profile of circulating plasma levels of proinflammatory cytokines differs in unstable angina from that in stable angina. Abbreviated Abstract. Multiple studies support a role for inflammation in the pathogenesis of coronary atherosclerosis and unstable cardiac syndromes. We measured plasma levels of interleukin-1 beta (IL-1beta), tumor necrosis factor alpha (TNF-alpha), and interleukin 6 (IL-6) in patients with stable and unstable coronary syndromes. Levels of IL-1beta and IL-6 were found to be elevated in patients with unstable coronary syndromes. No significant differences were found in the levels of TNF-alpha. Our results suggest that both IL-1beta and IL-6 contribute to the pathogenesis of unstable angina.
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