ArticleProceedings of the National Academy of Sciences of the United States of America2000
The Arabidopsis thaliana SOS2 gene encodes a protein kinase that is required for salt tolerance.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 307 papers.
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Who cites it
307 citing papers in PubMed.
- Functional characterization of citrus SOS genes reveals CsSOS2 as a key regulator of salinity tolerance in Carrizo citrange.Plant cell reports · 2026Article
- Whole Genome Sequencing, Comparative Genome Analysis, and Biotechnological Potential ofJournal of fungi (Basel, Switzerland) · 2026Article
- Alfalfa MsSOS2 confers salinity tolerance by promoting lateral root growth and regulating NaScientific reports · 2025Article
- Advances in deciphering the mechanisms of salt tolerance in Maize.Plant signaling & behavior · 2025Review
- Genome-wide characterization of NHX gene family in Medicago sativa under abiotic stress.BMC plant biology · 2025Article
- Learning fromInternational journal of molecular sciences · 2025Review
- SOS3 fromCells · 2025Article
- Diurnal Regulation of SOS Pathway and Sodium Excretion Underlying Salinity Tolerance of Vigna marina.Plant, cell & environment · 2025Article
- The phytochrome B signaling regulates salt-mediated seedling growth in the dark.Plant & cell physiology · 2025Article
- SOS2 phosphorylates FREE1 to regulate multi-vesicular body trafficking and vacuolar dynamics under salt stress.The Plant cell · 2025Article
- Genomic signatures of SnRKs highlighted conserved evolution within orchids and stress responses through ABA signaling in the Cymbidium ensifolium.BMC plant biology · 2025Article
- SALT OVERLY SENSITIVE2 and AMMONIUM TRANSPORTER1;1 contribute to plant salt tolerance by maintaining ammonium uptake.The Plant cell · 2025Article
- TaSnRK3.23B, a CBL-interacting protein kinase of wheat, confers drought stress tolerance by promoting ROS scavenging in Arabidopsis.BMC plant biology · 2025Article
- Salinity survival: molecular mechanisms and adaptive strategies in plants.Frontiers in plant science · 2025Review
- Review
- The CaGenes · 2024Article
- The transcription factor MdERF023 negatively regulates salt tolerance by modulating ABA signaling and NaPlant cell reports · 2024Article
- Transcriptome Analysis of the Regulatory Mechanisms of Holly (Plants (Basel, Switzerland) · 2024Article
- Sulfated peptides and their receptors: Key regulators of plant development and stress adaptation.Plant communications · 2024Review
- Molecular cloning and characterization of a salt overly sensitive3 (SOS3) gene from the halophyte Pongamia.Plant molecular biology · 2024Article
247 more citing papers are in PubMed but not listed here.
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5 authors.
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Abstract
In Arabidopsis thaliana, the Salt Overly Sensitive 2 (SOS2) gene is required for intracellular Na(+) and K(+) homeostasis. Mutations in SOS2 cause Na(+) and K(+) imbalance and render plants more sensitive toward growth inhibition by high Na(+) and low K(+) environments. We isolated the SOS2 gene through positional cloning. SOS2 is predicted to encode a serine/threonine type protein kinase with an N-terminal catalytic domain similar to that of the yeast SNF1 kinase. Sequence analyses of sos2 mutant alleles reveal that both the N-terminal catalytic domain and the C-terminal regulatory domain of SOS2 are functionally essential. The steady-state level of SOS2 transcript is up-regulated by salt stress in the root. Autophosphorylation assays show that SOS2 is an active protein kinase. In the recessive sos2-5 allele, a conserved glycine residue in the kinase catalytic domain is changed to glutamate. This mutation abolishes SOS2 autophosphorylation, indicating that SOS2 protein kinase activity is required for salt tolerance.
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