ArticleProceedings of the National Academy of Sciences of the United States of America2000
Potent induction of long-term CD8+ T cell memory by short-term IL-4 exposure during T cell receptor stimulation.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
28 citing papers in PubMed, 83 citations in OpenAlex.
- Memory Cells in Atopic Dermatitis: Paving the Way to Disease Modification.International journal of molecular sciences · 2026Review
- α-Galactosylceramide-expanded virtual memory CD8Frontiers in immunology · 2026Article
- Lymphocytes and monocytes undergo swift suppression of IL-10R, IL-6R, and IL-2Rβγ signaling under high concentrations of different cytokines.bioRxiv : the preprint server for biology · 2025Article
- ChronicAmerican journal of physiology. Heart and circulatory physiology · 2021Article
- A Correlation Between Differentiation Phenotypes of Infused T Cells and Anti-Cancer Immunotherapy.Frontiers in immunology · 2021Review
- Targeting IL-4 for the Treatment of Atopic Dermatitis.ImmunoTargets and therapy · 2020Review
- Identification of BALB/c Immune Markers Correlated with a Partial Protection to Leishmania infantum after Vaccination with a Rationally Designed Multi-epitope Cysteine Protease A Peptide-Based Nanovaccine.PLoS neglected tropical diseases · 2017Article
- Therapeutic vaccines for allergic disease.NPJ vaccines · 2017Article
- Evaluation of the immunogenicity and protective efficacy of killed Leishmania donovani antigen along with different adjuvants against experimental visceral leishmaniasis.Medical microbiology and immunology · 2015Article
- Epigenetic plasticity of Cd8a locus during CD8(+) T-cell development and effector differentiation and reprogramming.Nature communications · 2014Article
- Article
- Early Decision: Effector and Effector Memory T Cell Differentiation in Chronic Infection.Current immunology reviews · 2013Article
- Indoleamine 2,3-dioxygenase and metabolites protect murine lung allografts and impair the calcium mobilization of T cells.American journal of respiratory cell and molecular biology · 2012Article
- Article
- Tumor Therapy Applying Membrane-bound Form of Cytokines.Immune network · 2009Article
- Endogenously produced IL-4 nonredundantly stimulates CD8+ T cell proliferation.Journal of immunology (Baltimore, Md. : 1950) · 2009Article
- gp63 in stable cationic liposomes confers sustained vaccine immunity to susceptible BALB/c mice infected with Leishmania donovani.Infection and immunity · 2008Article
- Immunity and protection, the unfolding of a tale.Immunologic research · 2007Article
- Dysregulation of IL-15-mediated T-cell homeostasis in TGF-beta dominant-negative receptor transgenic mice.Blood · 2006Article
- IL-4 receptor expression on CD8+ T cells is required for the development of protective memory responses against liver stages of malaria parasites.The Journal of experimental medicine · 2005Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
An important goal of vaccination is to achieve long-term survival of functional memory T cells. Using a MHC-compatible adoptive transfer system, we show here that a short, 3-day IL-4 but not IL-2 or IL-12 exposure during in vitro T cell receptor stimulation of naive CD8(+) T cells induced long-lasting in vivo memory. Such long-term memory CD8(+) T cells expressed antigen-specific cytotoxicity and the potential for IFN-gamma and IL-4 production. Our results support the concept that functional T cell longevity can be regulated by cytokines during initial antigen encounter and provide a rational foundation for vaccine development. They also may have implications in formulating optimal therapeutic regimens of ex vivo expanded autologous cancer- and HIV-specific CD8(+) T cells. In addition, the availability of large numbers of memory CD8(+) T cells generated through our high-efficiency system should facilitate progress in the molecular dissection of CD8(+) T cell memory development.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.