ArticleProceedings of the National Academy of Sciences of the United States of America2000
The Arabidopsis SOS2 protein kinase physically interacts with and is activated by the calcium-binding protein SOS3.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 304 papers.
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304 citing papers in PubMed, 817 citations in OpenAlex.
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- Responses, Physiological and Molecular Mechanisms, and Mitigation Strategies of Grapevine Under Salt Stress.International journal of molecular sciences · 2026Review
- Functional characterization of citrus SOS genes reveals CsSOS2 as a key regulator of salinity tolerance in Carrizo citrange.Plant cell reports · 2026Article
- Salinity tolerance in wheat: rethinking the targets.Journal of experimental botany · 2026Review
- SALT OVERLY SENSITIVE 1 NaPlant, cell & environment · 2026Article
- Genome-wide analysis of the SOS2 gene family in melon (Cucumis melo L.) and functional characterization of MELO3C010334 in response to salt stress.BMC plant biology · 2026Article
- Genotype-dependent salt tolerance mechanisms in wheat-Thinopyrum introgression lines revealed by ion transporter gene expression and seedling phenotyping.Scientific reports · 2026Article
- From Model Plants to Staple Crops: Molecular Mechanisms of Plant Saline-Alkali Tolerance.Plants (Basel, Switzerland) · 2026Review
- Alfalfa MsSOS2 confers salinity tolerance by promoting lateral root growth and regulating NaScientific reports · 2025Article
- Goldilocks and the SOS pathway: Finding "just right" for growth after salt stress.The Plant cell · 2025Article
- SOS3 fromCells · 2025Article
- The transcription factor MdWRKY9 is involved in jasmonic acid-mediated salt stress tolerance in apple.Horticulture research · 2025Article
- SALT OVERLY SENSITIVE2 and AMMONIUM TRANSPORTER1;1 contribute to plant salt tolerance by maintaining ammonium uptake.The Plant cell · 2025Article
- Salinity survival: molecular mechanisms and adaptive strategies in plants.Frontiers in plant science · 2025Review
- Evolution and functional characterization of Populus salt stress-responsive calcineurin B-like protein-interacting protein kinases.Plant cell reports · 2024Article
- Molecular Regulation of Photosynthetic Carbon Assimilation in Oat Leaves Under Drought Stress.Plants (Basel, Switzerland) · 2024Article
- Heterologous Expression of Chrysanthemum TCP Transcription Factor CmTCP13 Enhances Salinity Tolerance inPlants (Basel, Switzerland) · 2024Article
- The transcription factor MdERF023 negatively regulates salt tolerance by modulating ABA signaling and NaPlant cell reports · 2024Article
- Transcriptome Analysis of the Regulatory Mechanisms of Holly (Plants (Basel, Switzerland) · 2024Article
- Molecular cloning and characterization of a salt overly sensitive3 (SOS3) gene from the halophyte Pongamia.Plant molecular biology · 2024Article
244 more citing papers are in PubMed but not listed here.
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
The Arabidopsis thaliana SOS2 and SOS3 genes are required for intracellular Na(+) and K(+) homeostasis and plant tolerance to high Na(+) and low K(+) environments. SOS3 is an EF hand type calcium-binding protein having sequence similarities with animal neuronal calcium sensors and the yeast calcineurin B. SOS2 is a serine/threonine protein kinase in the SNF1/AMPK family. We report here that SOS3 physically interacts with and activates SOS2 protein kinase. Genetically, sos2sos3 double mutant analysis indicates that SOS2 and SOS3 function in the same pathway. Biochemically, SOS2 interacts with SOS3 in the yeast two-hybrid system and in vitro binding assays. The interaction is mediated by the C-terminal regulatory domain of SOS2. SOS3 activates SOS2 protein kinase activity in a Ca(2+)-dependent manner. Therefore, SOS3 and SOS2 define a novel regulatory pathway important for the control of intracellular ion homeostasis and salt tolerance in plants.
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