ArticleThe Journal of cell biology2000
Proteins needed for vesicle budding from the Golgi complex are also required for the docking step of homotypic vacuole fusion.
Article in The Journal of cell biology, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
35 citing papers in PubMed.
- SNARE Proteins in Synaptic Vesicle Fusion.Advances in neurobiology · 2023Article
- Mitochondrial Tethers and Their Impact on Lifespan in Budding Yeast.Frontiers in cell and developmental biology · 2017Review
- AtVPS41-mediated endocytic pathway is essential for pollen tube-stigma interaction in Arabidopsis.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Emerging Insights into the Roles of Membrane Tethers from Analysis of Whole Organisms: The Tip of an Iceberg?Frontiers in cell and developmental biology · 2016Review
- Conserved regulators of Rag GTPases orchestrate amino acid-dependent TORC1 signaling.Cell discovery · 2016Review
- Glucose induces rapid changes in the secretome of Saccharomyces cerevisiae.Proteome science · 2014Article
- Membrane tethering.F1000prime reports · 2014Review
- Tracking of the dynamic localization of the Rab-specific HOPS subunits reveal their distinct interaction with Ypt7 and vacuoles.Cellular logistics · 2014Article
- The Vam6 and Gtr1-Gtr2 pathway activates TORC1 in response to amino acids in fission yeast.Journal of cell science · 2012Article
- News and Views into the SNARE Complexity in Arabidopsis.Frontiers in plant science · 2012Article
- Frontier of epilepsy research - mTOR signaling pathway.Experimental & molecular medicine · 2011Review
- The late stage of autophagy: cellular events and molecular regulation.Protein & cell · 2010Review
- HOPS prevents the disassembly of trans-SNARE complexes by Sec17p/Sec18p during membrane fusion.The EMBO journal · 2010Article
- Differential effects of TBC1D15 and mammalian Vps39 on Rab7 activation state, lysosomal morphology, and growth factor dependence.The Journal of biological chemistry · 2010Article
- The CORVET subunit Vps8 cooperates with the Rab5 homolog Vps21 to induce clustering of late endosomal compartments.Molecular biology of the cell · 2009Article
- HOPS interacts with Apl5 at the vacuole membrane and is required for consumption of AP-3 transport vesicles.Molecular biology of the cell · 2009Article
- The major role of the Rab Ypt7p in vacuole fusion is supporting HOPS membrane association.The Journal of biological chemistry · 2009Article
- Accumulation of rhodopsin in late endosomes triggers photoreceptor cell degeneration.PLoS genetics · 2009Article
- On and off membrane dynamics of the endoplasmic reticulum-golgi tethering factor p115 in vivo.Molecular biology of the cell · 2006Article
- Purification of active HOPS complex reveals its affinities for phosphoinositides and the SNARE Vam7p.The EMBO journal · 2006Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Vam2p/Vps41p is known to be required for transport vesicles with vacuolar cargo to bud from the Golgi. Like other VAM-encoded proteins, which are needed for homotypic vacuole fusion, we now report that Vam2p and its associated protein Vam6p/Vps39p are needed on each vacuole partner for homotypic fusion. In vitro vacuole fusion occurs in successive steps of priming, docking, and membrane fusion. While priming does not require Vam2p or Vam6p, the functions of these two proteins cannot be fulfilled until priming has occurred, and each is required for the docking reaction which culminates in trans-SNARE pairing. Consistent with their dual function in Golgi vesicle budding and homotypic fusion of vacuoles, approximately half of the Vam2p and Vam6p of the cell are recovered from cell lysates with purified vacuoles.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.