ArticleBritish journal of pharmacology2000
Enhanced blood pressure sensitivity to DOCA-salt treatment in endothelin ET(B) receptor-deficient rats.
Article in British journal of pharmacology, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 24 citations in OpenAlex.
- Heart Failure With Preserved Ejection Fraction: Heterogeneous Syndrome, Diverse Preclinical Models.Circulation research · 2022Review
- Age and Sex Differences in Heart Failure With Preserved Ejection Fraction.Frontiers in aging · 2022Review
- Application of Animal Models in Diabetic Cardiomyopathy.Diabetes & metabolism journal · 2021Review
- Heart failure with preserved ejection fraction: present status and future directions.Experimental & molecular medicine · 2019Review
- Bioconversion of Corticosterone into Corticosterone-Glucoside by Glucosyltransferase.Molecules (Basel, Switzerland) · 2018Article
- Murine Models of Heart Failure with Preserved Ejection Fraction: a "Fishing Expedition".JACC. Basic to translational science · 2017Article
- Endothelin.Pharmacological reviews · 2016Review
- Aldosterone modulates steroid receptor binding to the endothelin-1 gene (edn1).The Journal of biological chemistry · 2009Article
- Regulation of the epithelial Na+ channel by endothelin-1 in rat collecting duct.American journal of physiology. Renal physiology · 2008Article
- Role of endothelin and vasopressin in DOCA-salt hypertension.British journal of pharmacology · 2001Article
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6 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
The role of endothelin ET(B) receptor-mediated action in the development and maintenance of deoxycorticosterone acetate (DOCA)-salt-induced hypertension was evaluated using the spotting-lethal (sl) rat which carries a naturally occurring deletion in the ET(B) receptor gene. Homozygous (sl/sl) rats treated with DOCA-salt for 1 week exhibited an earlier onset of hypertension than heterozygous (sl/+) and wild-type (+/+) rats (systolic blood pressure, SBP; 156.7+/-3.4 versus 128.8+/-5.3 and 132.9+/-3.7 mmHg, respectively). Four weeks after the start of DOCA-salt treatment, homozygous rats developed marked hypertension, with a SBP of 206. 0+/-4.5 mmHg, compared with 184.8+/-10.7 mmHg in heterozygous and 164.3+/-4.8 mmHg in wild-type rats. Cardiovascular hypertrophy and renal dysfunction observed after 4-weeks treatment with DOCA-salt were more severe in homozygous rats, compared to wild-type and heterozygous animals. These evidences support strongly the view that ET(B) receptor-mediated actions are a protective factor in the pathogenesis of DOCA-salt-induced hypertension.
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