ArticleOncogene2000
The p44S10 locus, encoding a subunit of the proteasome regulatory particle, is amplified during progression of cutaneous malignant melanoma.
Article in Oncogene, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Targeting proteostasis for cancer therapy: current advances, challenges, and future perspectives.Molecular cancer · 2025Review
- A pilot study on the efficacy of a telomerase activator in regulating the proliferation of A375 skin cancer cell line.Molecular biology reports · 2024Article
- Silencing of carbonic anhydrase I enhances the malignant potential of exosomes secreted by prostatic tumour cells.Journal of cellular and molecular medicine · 2019Article
- Novel Biomarker Proteins in Chronic Lymphocytic Leukemia: Impact on Diagnosis, Prognosis and Treatment.PloS one · 2016Article
- Regulation of PSMB5 protein and β subunits of mammalian proteasome by constitutively activated signal transducer and activator of transcription 3 (STAT3): potential role in bortezomib-mediated anticancer therapy.The Journal of biological chemistry · 2014Article
- Dynein function and protein clearance changes in tumor cells induced by a Kunitz-type molecule, Amblyomin-X.PloS one · 2014Article
- Cytoprotection "gone astray": Nrf2 and its role in cancer.OncoTargets and therapy · 2014Review
- Article
- Inflammatory macrophages induce Nrf2 transcription factor-dependent proteasome activity in colonic NCM460 cells and thereby confer anti-apoptotic protection.The Journal of biological chemistry · 2011Article
- The ubiquitin-proteasome system as a prospective molecular target for cancer treatment and prevention.Current protein & peptide science · 2010Review
- Article
- Article
- An integrated analysis of genes and pathways exhibiting metabolic differences between estrogen receptor positive breast cancer cells.BMC cancer · 2007Article
- Functional cloning using pFB retroviral cDNA expression libraries.Molecular biotechnology · 2002Article
- Interferon-gamma reduces melanosomal antigen expression and recognition of melanoma cells by cytotoxic T cells.The American journal of pathology · 2002Article
Corrections and comments
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Authors and funding
18 authors.
Funding
Abstract
Gene amplification is frequently present in human tumors, although specific target genes relevant to many amplified loci remain unidentified. An expression cloning assay enabled identification of a candidate oncogene derived from human chromosome 3p14.1. The cDNA retrieved from morphologically transformed cells contained the full-length protein coding region and detected an abundant transcript in the same cells. Sequence analysis revealed identity with the wild-type sequence of p44S10, a highly conserved subunit of the 26S proteasome that exhibits similarity to the Arabidopsis fus6/cop11 family of signaling molecules. p44S10 gene copy number and mRNA expression were increased in association with segmental 1.8 - 11-fold chromosomal gains in cutaneous malignant melanoma cell lines (5/13; 40%) and tumors (2/40; 5%), and in breast cancer MCF-7 cells. Likewise, malignant progression of human radial growth phase WM35 melanoma cells was associated with amplification and increased expression of endogenous p44S10, and increased expression of p44S10 was sufficient to induce proliferation of WM35 cells in vivo. The results demonstrate segmental copy number gains within chromosome 3p in cutaneous malignant melanoma and suggest that deregulation of a proteasome regulatory particle subunit may contribute to the malignant phenotype.
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Registered trials
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