ArticleThorax2000
Frequent paracetamol use and asthma in adults.
Article in Thorax, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers, 3 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
48 citing papers in PubMed, 3 syntheses or guidelines pooled it, 227 citations in OpenAlex.
- Risk of wheezing and asthma exacerbation in children treated with paracetamol versus ibuprofen: a systematic review and meta-analysis of randomised controlled trials.BMC pulmonary medicine · 2020Pooled it
- Acetaminophen (paracetamol) for the common cold in adults.The Cochrane database of systematic reviews · 2013Pooled it
- The use of analgesics in patients with asthma.Drug safety · 2001Pooled it
- Randomised placebo-controlled study of the effect of paracetamol on asthma severity in adults.BMJ open · 2014Trial
- Trial
- Asthma Inception: Epidemiologic Risk Factors and Natural History Across the Life Course.American journal of respiratory and critical care medicine · 2024Review
- Acetaminophen for the patent ductus arteriosus: has safety been adequately demonstrated?Journal of perinatology : official journal of the California Perinatal Association · 2023Review
- Racing against time: leveraging preclinical models to understand pulmonary susceptibility to perinatal acetaminophen exposures.American journal of physiology. Lung cellular and molecular physiology · 2022Review
- The association between exacerbation of chronic obstructive pulmonary disease and timing of paracetamol use: a cohort study in elderly Australians.Respiratory research · 2022Article
- Pulmonary implications of acetaminophen exposures independent of hepatic toxicity.American journal of physiology. Lung cellular and molecular physiology · 2021Article
- Acetaminophen and the Developing Lung: Could There Be Lifelong Consequences?The Journal of pediatrics · 2021Review
- Paracetamol-Induced Glutathione Consumption: Is There a Link With Severe COVID-19 Illness?Frontiers in pharmacology · 2020Article
- Acetaminophen is both bronchodilatory and bronchoprotective in human precision cut lung slice airways.Xenobiotica; the fate of foreign compounds in biological systems · 2019Article
- E-Synthesis: A Bayesian Framework for Causal Assessment in Pharmacosurveillance.Frontiers in pharmacology · 2019Article
- Article
- Long-term adverse effects of paracetamol - a review.British journal of clinical pharmacology · 2018Review
- Leptin receptor gene polymorphisms and sex modify the association between acetaminophen use and asthma among young adults: results from two observational studies.Respiratory research · 2018Observational
- Extrahepatic toxicity of acetaminophen: critical evaluation of the evidence and proposed mechanisms.Journal of clinical and translational research · 2018Review
- Investigation of possible risk factors in the development of seasonal allergic conjunctivitis.International journal of ophthalmology · 2018Article
- TRPA1 gene polymorphisms and childhood asthma.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2017Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe pulmonary antioxidant glutathione may limit airway inflammation in asthma. Since paracetamol (acetaminophen) depletes the lung of glutathione in animals, a study was undertaken to investigate whether frequent use in humans was associated with asthma.
methodsInformation was collected on the use of analgesics as part of a population based case-control study of dietary antioxidants and asthma in adults aged 16-49 years registered with 40 general practices in Greenwich, South London. The frequency of use of paracetamol and aspirin was compared in 664 individuals with asthma and in 910 without asthma. Asthma was defined by positive responses to questions about asthma attacks, asthma medication, or waking at night with shortness of breath. The association between analgesic use and severity of disease amongst asthma cases, as measured by a quality of life score, was also examined.
resultsParacetamol use was positively associated with asthma. After controlling for potential confounding factors the odds ratio for asthma, compared with never users, was 1.06 (95% CI 0.77 to 1.45) in infrequent users (<monthly), 1.22 (0.87 to 1.72) in monthly users, 1. 79 (1.21 to 2.65) in weekly users, and 2.38 (1.22 to 4.64) in daily users (p (trend) = 0.0002). This association was present in users and non-users of aspirin and was stronger when cases with more severe disease were compared with controls; amongst cases increasing paracetamol use was associated with more severe disease. Frequency of aspirin use was not associated with asthma when cases as a whole were compared with controls, nor with severity of asthma amongst cases. Frequent paracetamol use was positively associated with rhinitis, but aspirin use was not.
conclusionsFrequent use of paracetamol may contribute to asthma morbidity and rhinitis in adults.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.