ArticleInfection and immunity2000
Macrophage migration inhibitory factor release by macrophages after ingestion of Plasmodium chabaudi-infected erythrocytes: possible role in the pathogenesis of malarial anemia.
Article in Infection and immunity, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
48 citing papers in PubMed, 1 synthesis or guideline pooled it, 134 citations in OpenAlex.
- Association between the MIF-173G/C Polymorphism and Serum MIF levels with Pulmonary Tuberculosis: A Meta-analysis.Scientific reports · 2017Pooled it
- T cell and monocyte/macrophage activation markers associate with adverse outcome, but give limited prognostic value in anemic patients with heart failure: results from RED-HF.Clinical research in cardiology : official journal of the German Cardiac Society · 2019Trial
- Emerging Role of Splenic Macrophage in Malaria Pathogenesis and Immunity.Immunity, inflammation and disease · 2025Review
- Malaria and dyserythropoiesis: a mini review.Frontiers in cellular and infection microbiology · 2025Review
- Molecular regulation of NLRP3 inflammasome activation during parasitic infection.Bioscience reports · 2024Review
- Cytokine profiles in adults with imported malaria.Scientific reports · 2023Article
- Immune Mechanisms in Inflammatory Anemia.Annual review of immunology · 2023Review
- Macrophage migration inhibitory factor contributes to immunopathogenesis duringFrontiers in cellular and infection microbiology · 2022Article
- Automated Assay of a Four-Protein Biomarker Panel for Improved Detection of Ovarian Cancer.Cancers · 2021Article
- Role of Host and Parasite MIF Cytokines duringTropical medicine and infectious disease · 2020Review
- AcuteFrontiers in microbiology · 2020Article
- Macrophage migration inhibitory factor deficiency enhances immune response to Nippostrongylus brasiliensis.Mucosal immunology · 2017Article
- Macrophage migration inhibitory factor is an endogenous regulator of stress-induced extramedullary erythropoiesis.Histochemistry and cell biology · 2016Article
- Erythropoiesis in Malaria Infections and Factors Modifying the Erythropoietic Response.Anemia · 2016Review
- Maturation of Plasmodium falciparum in multiply infected erythrocytes and the potential role in malaria pathogenesis.Parasitology research · 2014Article
- Helminth parasites alter protection against Plasmodium infection.BioMed research international · 2014Review
- Malarial pigment hemozoin and the innate inflammatory response.Frontiers in immunology · 2014Review
- Novel anti-inflammatory activity of epoxyazadiradione against macrophage migration inhibitory factor: inhibition of tautomerase and proinflammatory activities of macrophage migration inhibitory factor.The Journal of biological chemistry · 2012Article
- Intervillous macrophage migration inhibitory factor is associated with adverse birth outcomes in a study population in Central India.PloS one · 2012Article
- Macrophage migration inhibitory factor in protozoan infections.Journal of parasitology research · 2012Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
Human falciparum malaria, caused by Plasmodium falciparum infection, results in 1 to 2 million deaths per year, mostly children under the age of 5 years. The two main causes of death are severe anemia and cerebral malaria. Malarial anemia is characterized by parasite red blood cell (RBC) destruction and suppression of erythropoiesis (the mechanism of which is unknown) in the presence of a robust host erythropoietin response. The production of a host-derived erythropoiesis inhibitor in response to parasite products has been implicated in the pathogenesis of malarial anemia. The identity of this putative host factor is unknown, but antibody neutralization studies have ruled out interleukin-1beta, tumor necrosis factor alpha, and gamma interferon while injection of interleukin-12 protects susceptible mice against lethal P. chabaudi infection. In this study, we report that ingestion of P. chabaudi-infected erythrocytes or malarial pigment (hemozoin) induces the release of macrophage migration inhibitory factor (MIF) from macrophages. MIF, a proinflammatory mediator and counter-regulator of glucocorticoid action, inhibits erythroid (BFU-E), multipotential (CFU-GEMM), and granulocyte-macrophage (CFU-GM) progenitor-derived colony formation. MIF was detected in the sera of P. chabaudi-infected BALB/c mice, and circulating levels correlated with disease severity. Liver MIF immunoreactivity increased concomitant with extensive pigment and parasitized RBC deposition. Finally, MIF was elevated three- to fourfold in the spleen and bone marrow of P. chabaudi-infected mice with active disease, as compared to early disease, or of uninfected controls. In summary, the present results suggest that MIF may be a host-derived factor involved in the pathophysiology of malaria anemia.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.