ArticleInfection and immunity2000
Roles of interleukin-12 and gamma interferon in murine Chlamydia pneumoniae infection.
Article in Infection and immunity, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
21 citing papers in PubMed, 61 citations in OpenAlex.
- Enhancement of Macrophage Immunity against Chlamydial Infection by Natural Killer T Cells.Cells · 2024Article
- Chlamydia pneumoniae induces interleukin-12 responses in peripheral blood mononuclear cells in asthma and the role of toll like receptor 2 versus 4: a pilot study.Irish journal of medical science · 2017Article
- Chlamydial lung infection induces transient IL-9 production which is redundant for host defense against primary infection.PloS one · 2015Article
- Interleukin-22 promotes T helper 1 (Th1)/Th17 immunity in chlamydial lung infection.Molecular medicine (Cambridge, Mass.) · 2014Article
- T cell-mediated host immune defenses in the lung.Annual review of immunology · 2013Review
- Type 1 T-cell responses in chlamydial lung infections are associated with local MIP-1alpha response.Cellular & molecular immunology · 2010Article
- The acute phase reactant response to respiratory infection with Chlamydia pneumoniae: implications for the pathogenesis of atherosclerosis.Microbes and infection · 2010Article
- The contribution of interleukin-12/interferon-gamma axis in protection against neonatal pulmonary Chlamydia muridarum challenge.Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research · 2010Article
- Differences in innate immune responses correlate with differences in murine susceptibility to Chlamydia muridarum pulmonary infection.Immunology · 2010Article
- Critical role of the interleukin-17/interleukin-17 receptor axis in regulating host susceptibility to respiratory infection with Chlamydia species.Infection and immunity · 2009Article
- Diverse myeloid and lymphoid cell subpopulations produce gamma interferon during early innate immune responses to Francisella tularensis live vaccine strain.Infection and immunity · 2008Article
- Genetic control of susceptibility to pulmonary infection with Chlamydia pneumoniae in the mouse.Genes and immunity · 2008Article
- Interleukin-12 and host defense against murine Pneumocystis pneumonia.Infection and immunity · 2008Article
- Host cell responses to Chlamydia pneumoniae in gamma interferon-induced persistence overlap those of productive infection and are linked to genes involved in apoptosis, cell cycle, and metabolism.Infection and immunity · 2007Article
- Divergent roles of IL-23 and IL-12 in host defense against Klebsiella pneumoniae.The Journal of experimental medicine · 2005Article
- Induction of proinflammatory cytokines in human lung epithelial cells during Chlamydia pneumoniae infection.Infection and immunity · 2003Article
- Identification of Chlamydia pneumoniae-derived mouse CD8 epitopes.Infection and immunity · 2002Article
- In vivo clearance of an intracellular bacterium, Francisella tularensis LVS, is dependent on the p40 subunit of interleukin-12 (IL-12) but not on IL-12 p70.Infection and immunity · 2002Article
- Chlamydia pneumoniae infects and multiplies in lymphocytes in vitro.Infection and immunity · 2001Article
- Chlamydia pneumoniae exacerbates aortic inflammatory foci caused by murine cytomegalovirus infection in normocholesterolemic mice.Clinical and diagnostic laboratory immunology · 2001Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
BALB/c and strain 129 mice infected intranasally with Chlamydia pneumoniae displayed a moderate-to-severe inflammation in the lungs and produced interleukin-12 (IL-12), gamma interferon (IFN-gamma), tumor necrosis factor alpha (TNF-alpha), and IL-10, with peak levels on days 1 to 3 postinfection (p.i.), returning to basal levels by day 16 p.i. Anti-IL-12 treatment resulted in less-severe pathological changes but higher bacterial titers on days 3 and 7 p.i. By day 16 p.i., the inflammatory responses of control antibody-treated mice subsided. The bacterial titers of both anti-IL-12- and control antibody-treated mice decreased within 3 weeks to marginally detectable levels. Anti-IL-12 treatment significantly reduced lung IFN-gamma production and in vitro spleen cell IFN-gamma production in response to either C. pneumoniae or concanavalin A. In gamma-irradiated infected mice, cytokine production was delayed, and this delay correlated with high bacterial titers in the lungs. Following C. pneumoniae infection, 129 mice lacking the IFN-gamma receptor alpha chain gene (G129 mice) produced similar IL-12 levels and exhibited similarly severe pathological changes but had higher bacterial titers than 129 mice. However, by day 45 p.i., bacterial titers became undetectable in both wild-type 129 and G129 mice. Thus, during C. pneumoniae lung infection, IL-12, more than IFN-gamma, plays a role in pulmonary-cell infiltration. IFN-gamma and IL-12, acting mostly through its induction of IFN-gamma and Th1 responses, play an important role in controlling acute C. pneumoniae infection in the lungs, but eventually all mice control the infection to undetectable levels by IL-12- and IFN-gamma-independent mechanisms.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.