Evidence map›Paper›PMID 10722499›Full record

Trial reportAntimicrobial agents and chemotherapy2000

Antimalarial bioavailability and disposition of artesunate in acute falciparum malaria.

P Newton, Y Suputtamongkol, P Teja-Isavadharm, S Pukrittayakamee, V Navaratnam, I Bates, N White

Open access · greenAbstract readClinical TrialRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Antimicrobial agents and chemotherapy, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 66 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
66citing papers in PubMed, 3 pooled it
8.7field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

66 citing papers in PubMed, 3 syntheses or guidelines pooled it, 154 citations in OpenAlex.

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6 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 6 institutions in 3 countries.

P NewtonFaculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.
Y Suputtamongkol
P Teja-Isavadharm
S Pukrittayakamee
V Navaratnam
I Bates
N White
Mahidol Oxford Tropical Medicine Research Unit · THArmed Forces Research Institute of Medical Science · THLiverpool School of Tropical Medicine · GBMahidol University · THSiriraj Hospital · THUniversiti Sains Malaysia · MY

Funding

Wellcome Trust
6 · The paper itself

Abstract

The pharmacokinetic properties of oral and intravenous artesunate (2 mg/kg of body weight) were studied in 19 adult patients with acute uncomplicated Plasmodium falciparum malaria by using a randomized crossover design. A sensitive bioassay was used to measure the antimalarial activity in plasma which results from artesunate and its principal metabolite, dihydroartemisinin. The oral study was repeated with 15 patients during convalescence. The mean absolute oral bioavailability of the antimalarial agent in patients with acute malaria was 61% (95% confidence interval [CI], 52 to 70%). The absorption and elimination of oral artesunate were rapid, with a mean elimination half-life of antimalarial activity of 43 min (95% CI, 33 to 53 min). Following oral administration to patients with acute falciparum malaria, peak antimalarial activity in plasma and the area under the plasma concentration-time curve were approximately double those during convalescence and the apparent volume of distribution and clearance were approximately half those during convalescence (P < or = 0.005). Acute malaria is associated with a significant reduction in the clearance of artesunate-associated antimalarial activity.

Indexed as

ArtemisininsAdministration, OralAdolescentAdultAntimalarialsArea Under CurveArtesunateBiological AvailabilityChromatography, High Pressure LiquidElectrochemistryFemaleHalf-LifeHumansInjections, IntravenousIntestinal AbsorptionMalaria, FalciparumAntimalarialsArtemisininsArtesunateSesquiterpenes

Identifiers

PMID10722499
PMCPMC89800
OpenAlexW2096407013

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.