ArticleAntimicrobial agents and chemotherapy2000
Pefloxacin-induced achilles tendon toxicity in rodents: biochemical changes in proteoglycan synthesis and oxidative damage to collagen.
Article in Antimicrobial agents and chemotherapy, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.
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Who cites it
28 citing papers in PubMed, 1 synthesis or guideline pooled it, 96 citations in OpenAlex.
- Fluoroquinolones and tendinopathy: a guide for athletes and sports clinicians and a systematic review of the literature.Journal of athletic trainingPooled it
- Levofloxacin-associated tendon disorders: Sex-, age-, and route-specific disproportionality analysis using FAERS and JADER.PloS one · 2026Article
- Fluoroquinolone-Induced Achilles Tendon Damage: Structural and Biochemical Insights into Collagen Type I Alterations.International journal of molecular sciences · 2025Review
- Article
- Fluoroquinolone-Mediated Tendinopathy and Tendon Rupture.Pharmaceuticals (Basel, Switzerland) · 2025Review
- Susceptibility to radiation adverse effects in veterans with Gulf War illness and healthy civilians.Scientific reports · 2024Article
- Animal model for tendinopathy.Journal of orthopaedic translation · 2023Review
- Article
- Roles of Oxidative Stress in Acute Tendon Injury and Degenerative Tendinopathy-A Target for Intervention.International journal of molecular sciences · 2022Review
- Fluoroquinolone and no risk of Achilles-tendinopathy in childhood pneumonia under eight years of age-a nationwide retrospective cohort.Journal of thoracic disease · 2021Article
- Article
- Recovery of Tendon Characteristics by Inhibition of Aberrant Differentiation of Tendon-Derived Stem Cells from Degenerative Tendinopathy.International journal of molecular sciences · 2020Article
- Early postoperative fluoroquinolone use is associated with an increased revision rate after arthroscopic rotator cuff repair.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2017Article
- Treatment of the Fluoroquinolone-Associated Disability: The Pathobiochemical Implications.Oxidative medicine and cellular longevity · 2017Review
- Nonantibiotic Effects of Fluoroquinolones in Mammalian Cells.The Journal of biological chemistry · 2015Article
- Determination of protein carbonyls in plasma, cell extracts, tissue homogenates, isolated proteins: Focus on sample preparation and derivatization conditions.Redox biology · 2015Review
- Work related etiology of de Quervain's tenosynovitis: a case-control study with prospectively collected data.BMC musculoskeletal disorders · 2015Article
- Amoxillin- and pefloxacin-induced cholesterogenesis and phospholipidosis in rat tissues.Lipids in health and disease · 2015Article
- Fatigue loading of tendon.International journal of experimental pathology · 2013Review
- Oxidative stress induced by fluoroquinolones on treatment for complicated urinary tract infections in Indian patients.Journal of young pharmacists : JYP · 2011Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Despite a relatively low incidence of serious side effects, fluoroquinolones and the fluoroquinolone pefloxacin have been reported to occasionally promote tendinopathy that might result in the complication of spontaneous rupture of tendons. In the present study, we investigated in rodents the intrinsic deleterious effect of pefloxacin (400 mg/kg of body weight) on Achilles tendon proteoglycans and collagen. Proteoglycan synthesis was determined by measurement of in vivo and ex vivo radiosulfate incorporation in mice. Collagen oxidative modifications were measured by carbonyl derivative detection by Western blotting. An experimental model of tendinous ischemia (2 h) and reperfusion (3 days) was achieved in rats. Biphasic changes in proteoglycan synthesis were observed after a single administration of pefloxacin, consisting of an early inhibition followed by a repair-like phase. The depletion phase was accompanied by a marked decrease in the endogenous serum sulfate level and a concomitant increase in the level of sulfate excretion in urine. Studies of ex vivo proteoglycan synthesis confirmed the in vivo results that were obtained. The decrease in proteoglycan anabolism seemed to be a direct effect of pefloxacin on tissue metabolism rather than a consequence of the low concentration of sulfate. Pefloxacin treatment for several days induced oxidative damage of type I collagen, with the alterations being identical to those observed in the experimental tendinous ischemia and reperfusion model. Oxidative damage was prevented by coadministration of N-acetylcysteine (150 mg/kg) to the mice. These results provide the first experimental evidence of a pefloxacin-induced oxidative stress in the Achilles tendon that altered proteoglycan anabolism and oxidized collagen.
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