ArticleGenome research2000
Evolution of the neuropeptide Y receptor family: gene and chromosome duplications deduced from the cloning and mapping of the five receptor subtype genes in pig.
Article in Genome research, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 75 citations in OpenAlex.
- Therapeutic potential of modulating endogenous PYY expression for controlling overweight and obesity: a narrative review.Frontiers in nutrition · 2026Review
- Neuropeptide Y receptor Y8b (Journal of Zhejiang University. Science. B · 2024Article
- Neuropeptide Y receptor Y2 (Frontiers in cell and developmental biology · 2023Article
- Avian Neuropeptide Y: Beyond Feed Intake Regulation.Veterinary sciences · 2022Review
- Article
- Neuropeptide Y1 receptor inhibits cell growth through inactivating mitogen-activated protein kinase signal pathway in human hepatocellular carcinoma.Medical oncology (Northwood, London, England) · 2016Article
- Neuropeptide Y receptor gene expression in the primate amygdala predicts anxious temperament and brain metabolism.Biological psychiatry · 2014Article
- Pancreatic polypeptide is recognized by two hydrophobic domains of the human Y4 receptor binding pocket.The Journal of biological chemistry · 2014Article
- Article
- Ancient Grandeur of the Vertebrate Neuropeptide Y System Shown by the Coelacanth Latimeria chalumnae.Frontiers in neuroscience · 2013Article
- Analysis of multiple polymorphisms in the bovine neuropeptide Y5 receptor gene and structural modelling of the encoded protein.Molecular biology reports · 2012Article
- Roles of hormones in taste signaling.Results and problems in cell differentiation · 2010Review
- Neuropeptide Y receptor genes are associated with alcohol dependence, alcohol withdrawal phenotypes, and cocaine dependence.Alcoholism, clinical and experimental research · 2008Article
- Comprehensive clarification of two paralogous interleukin 4/13 loci in teleost fish.Immunogenetics · 2008Article
- Early vertebrate chromosome duplications and the evolution of the neuropeptide Y receptor gene regions.BMC evolutionary biology · 2008Article
- Novel neuropeptide Y Y2-like receptor subtype in zebrafish and frogs supports early vertebrate chromosome duplications.Journal of molecular evolution · 2004Article
- Numerous groups of chromosomal regional paralogies strongly indicate two genome doublings at the root of the vertebrates.Journal of structural and functional genomics · 2003Review
- The human Hox-bearing chromosome regions did arise by block or chromosome (or even genome) duplications.Genome research · 2002Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Neuropeptide Y (NPY) receptors mediate a variety of physiological responses including feeding and vasoconstriction. To investigate the evolutionary events that have generated this receptor family, we have sequenced and determined the chromosomal localizations of all five presently known mammalian NPY receptor subtype genes in the domestic pig, Sus scrofa (SSC). The orthologs of the Y(1) and Y(2) subtypes display high amino acid sequence identities between pig, human, and mouse (92%-94%), whereas the Y(4), Y(5), and y(6) subtypes display lower identities (76%-87%). The lower identity of Y(5) is due to high sequence divergence in the large third intracellular loop. The NPY1R, NPY2R, and NPY5R receptor genes were localized to SSC8, the NPY4R to SSC14, and NPY6R to SSC2. Our comparisons strongly suggest that the tight cluster of NPY1R, NPY2R, and NPY5R on human chromosome 4 (HSA4) represents the ancestral configuration, whereas the porcine cluster has been split by two inversions on SSC8. These 3 genes, along with adjacent genes from 14 other gene families, form a cluster on HSA4 with extensive similarities to a cluster on HSA5, where NPY6R and >13 other paralogs reside, as well as another large cluster on HSA10 that includes NPY4R. Thus, these gene families have expanded through large-scale duplications. The sequence comparisons show that the NPY receptor triplet NPY1R-NPY2R-NPY5R existed before these large-scale duplications.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.