ArticleJournal of neuro-oncology1999
Analysis of proliferation and apoptosis in brain gliomas: prognostic and clinical value.
Article in Journal of neuro-oncology, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 1 of them a synthesis that pooled it.
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Who cites it
32 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Clinical neuropathology practice guide 3-2013: levels of evidence and clinical utility of prognostic and predictive candidate brain tumor biomarkers.Clinical neuropathologyGuideline
- Prognostic factors to predict postoperative survival in patients with recurrent glioblastoma.World neurosurgery: X · 2024Article
- Oxidative Stress-Part of the Solution or Part of the Problem in the Hypoxic Environment of a Brain Tumor.Antioxidants (Basel, Switzerland) · 2020Article
- Extended disease-free interval of 6 years in a recurrent glioblastoma multiforme patient treated with G207 oncolytic viral therapy.Oncolytic virotherapy · 2015Article
- Patterns of failure after multimodal treatments for high-grade glioma: effectiveness of MIB-1 labeling index.Radiation oncology (London, England) · 2012Article
- Specific expression profile and prognostic significance of peroxiredoxins in grade II-IV astrocytic brain tumors.BMC cancer · 2010Article
- Survivin as an immunotherapeutic target for adult and pediatric malignant brain tumors.Cancer immunology, immunotherapy : CII · 2010Review
- Prognostic significance of growth kinetics in newly diagnosed glioblastomas revealed by combining serial imaging with a novel biomathematical model.Cancer research · 2009Article
- Multiparametric characterization of grade 2 glioma subtypes using magnetic resonance spectroscopic, perfusion, and diffusion imaging.Translational oncology · 2009Article
- Article
- Unrepresentative astrocytoma biopsy sampling is partly overcome by assessment of the MIB-1-labelled growth fraction.Journal of clinical pathology · 2007Article
- Immunohistochemical expression of peripheral benzodiazepine receptors in human astrocytomas and its correlation with grade of malignancy, proliferation, apoptosis and survival.Journal of neuro-oncology · 2007Article
- Apoptosis and proliferation: correlation with p53 in astrocytic tumours.Journal of neuro-oncology · 2005Article
- Prognostic significance of the immunohistochemical index of survivin in glioma: a comparative study with the MIB-1 index.Journal of neuro-oncology · 2005Article
- Apoptotic markers for primary brain tumor prognosis.Journal of neuro-oncology · 2005Review
- Apoptosis in gliomas: molecular mechanisms and therapeutic implications.Journal of neuro-oncology · 2004Review
- Correlation of in vitro infiltration with glioma histological type in organotypic brain slices.British journal of cancer · 2004Article
- Increased hMSH2 protein expression in glioblastoma multiforme.Journal of neuro-oncology · 2004Article
- Proliferation and aneusomy predict survival of young patients with astrocytoma grade II.British journal of cancer · 2003Article
- Apoptosis in glioma cells: review and analysis of techniques used for study with focus on the laser scanning cytometer.Journal of neuro-oncology · 2003Review
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
With the introduction of new (immuno-)histochemical techniques it is now possible to assess rates of proliferation and apoptosis in brain gliomas using archival paraffin embedded material. As proliferation and apoptosis are related to tumour growth rate quantification of these processes has prognostic value and is related to tumour grading. In this study we assessed the proliferation rate by measuring the Ki-67 labelling index using the MIB-1 antibody (MIB-LI) and the apoptotic rate using the in situ labelling of DNA strand breaks with TUNEL (TUNEL-LI) in 315 supratentorial gliomas. MIB-LI and TUNEL-LI in astrocytomas (A) where significantly lower compared to anaplastic astrocytomas (AA), glioblastomas (GBM) and oligodendroglial tumours [oligodendrogliomas (O) and anaplastic oligodendrogliomas (AO)]. MIB-LI and TUNEL-LI were significantly lower in AA compared to GBM. In astrocytic tumours MIB-LI and TUNEL-LI appeared to be correlated. As the distinction between A and AA is of clinical value but can be difficult histomorphologically we analysed the prognostic value of MIB-LI and TUNEL-LI in gliomas with particular emphasis on A and AA. MIB-LI below 10% was of prognostic value in A and AA, O and AO but not in GBM on univariate survival analysis. TUNEL-LI was of no prognostic value. With multivariate survival analysis MIB-LI lost prognostic significance in O and AO. Astrocytomas with a gemistocytic component (AG) are similar to A with respect to survival and MIB-LI and TUNEL-LI. MIB-LI is of independent prognostic value in A and AA. Assessment of MIB-LI in A and AA can be used as an aid in distinguishing A and AA.
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Registered trials
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