ArticleThe Journal of physiology2000
The sustained inward current and inward rectifier K+ current in pacemaker cells dissociated from rat sinoatrial node.
Article in The Journal of physiology, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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Who cites it
36 citing papers in PubMed, 86 citations in OpenAlex.
- Pacemaker Channels and the Chronotropic Response in Health and Disease.Circulation research · 2024Review
- Characterization of sinoatrial automaticity in Microcebus murinus to study the effect of aging on cardiac activity and the correlation with longevity.Scientific reports · 2023Article
- Frequency-Dependent Properties of the Hyperpolarization-Activated Cation Current, IInternational journal of molecular sciences · 2022Article
- Biomaterial-induced conversion of quiescent cardiomyocytes into pacemaker cells in rats.Nature biomedical engineering · 2022Article
- Structural and Electrical Remodeling of the Sinoatrial Node in Diabetes: New Dimensions and Perspectives.Frontiers in endocrinology · 2022Review
- Initiation and entrainment of multicellular automaticity via diffusion limited extracellular domains.Biophysical journal · 2021Article
- Physiological Roles of the Rapidly Activated Delayed Rectifier KInternational journal of molecular sciences · 2021Article
- Cardiac Pacemaker Dysfunction Arising From Different Studies of Ion Channel Remodeling in the Aging Rat Heart.Frontiers in physiology · 2020Article
- Rat caval vein myocardium undergoes changes in conduction characteristics during postnatal ontogenesis.Pflugers Archiv : European journal of physiology · 2019Article
- Sinus node-like pacemaker mechanisms regulate ectopic pacemaker activity in the adult rat atrioventricular ring.Scientific reports · 2019Article
- Mechanisms Underlying Spontaneous Action Potential Generation Induced by Catecholamine in Pulmonary Vein Cardiomyocytes: A Simulation Study.International journal of molecular sciences · 2019Article
- Kir2 inward rectification-controlled precise and dynamic balances between Kir2 and HCN currents initiate pacemaking activity.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2018Article
- Heterogeneous functional expression of the sustained inward NaPflugers Archiv : European journal of physiology · 2018Article
- The Pattern of mRNA Expression Is Changed in Sinoatrial Node from Goto-Kakizaki Type 2 Diabetic Rat Heart.Journal of diabetes research · 2018Article
- A Singular Role of IStem cell reviews and reports · 2017Article
- CaScientific reports · 2017Article
- Mechanisms underlying the cardiac pacemaker: the role of SK4 calcium-activated potassium channels.Acta pharmacologica Sinica · 2016Review
- Article
- PP2 prevents β-adrenergic stimulation of cardiac pacemaker activity.Journal of cardiovascular pharmacology · 2014Article
- Metabolic syndrome remodels electrical activity of the sinoatrial node and produces arrhythmias in rats.PloS one · 2013Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
1. Myocytes were dissociated from the sinoatrial (SA) node of rat heart using a new enzymatic dissociation technique. Only a small number of isolated SA node myocytes showed regular rhythmic contractions and spontaneous action potentials, and these were used in the present study. 2. The spontaneous action potential was resistant to TTX, and the action potential parameters were similar to those of rabbit and guinea-pig pacemaker cells. Major time- and voltage-dependent currents were the delayed rectifier K+ current IKr, the L-type Ca2+ current ICa,L and the sodium current INa. The hyperpolarization-activated cation current (If) was recorded from approximately 50 % of the cells with hyperpolarization beyond -90 mV. 3. The instantaneous current jump at the onset of a hyperpolarizing pulse showed inward rectification and was largely blocked by Ba2+. This Ba2+-sensitive current corresponded well to the inward rectifier K+ current (IK1), although it was much smaller in amplitude than in the ventricle. 4. A sustained inward current was activated on depolarization from -80 mV to the voltage range of slow diastolic depolarization. The current was blocked by nicardipine, enlarged by isoprenaline and was insensitive to removal of external Ca2+. These characteristics were similar to the sustained inward current, Ist, previously described in the rabbit and guinea-pig SA node cells. 5. The role of Ist was considered by constructing empirical equations, which were applied to the experimental record of the action potential. It is demonstrated that the voltage-dependent activation of Ist constitutes a positive feedback loop with the depolarization of the membrane.
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