ArticleProceedings of the National Academy of Sciences of the United States of America2000
Probing essential oil biosynthesis and secretion by functional evaluation of expressed sequence tags from mint glandular trichomes.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 97 papers.
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Who cites it
97 citing papers in PubMed, 309 citations in OpenAlex.
- Plant metabolism: Zoom in to the single-cell level.Plant physiology · 2025Review
- Transgressive segregation affects essential oil composition in a model mint population.The New phytologist · 2025Article
- Advances in promoter engineering strategies for enhanced recombinant protein expression in plants.Frontiers in plant science · 2025Review
- A century of studying plant secondary metabolism-From "what?" to "where, how, and why?"Plant physiology · 2024Review
- Characterization of a Unique Pair of Ferredoxin and Ferredoxin NADPPlants (Basel, Switzerland) · 2024Article
- Lavandula Species, Their Bioactive Phytochemicals, and Their Biosynthetic Regulation.International journal of molecular sciences · 2023Review
- The non-specific lipid transfer protein McLTPII.9 ofFrontiers in plant science · 2023Article
- Biochemical basis for the formation of organ-specific volatile blends in mint.Frontiers in plant science · 2023Article
- Diploid mint (M. longifolia) can produce spearmint type oil with a high yield potential.Scientific reports · 2021Article
- Sclareol and linalyl acetate are produced by glandular trichomes through the MEP pathway.Horticulture research · 2021Article
- Processed false yam seed meals in broiler chicken diets: effects on feed preference and apparent nutrient digestibility.Tropical animal health and production · 2020Article
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- Characterization of a sweet basil acyltransferase involved in eugenol biosynthesis.Journal of experimental botany · 2020Article
- Comparative temporal metabolomics studies to investigate interspecies variation in three Ocimum species.Scientific reports · 2020Article
- Medically Useful Plant Terpenoids: Biosynthesis, Occurrence, and Mechanism of Action.Molecules (Basel, Switzerland) · 2019Review
- Gene Networks Underlying Cannabinoid and Terpenoid Accumulation in Cannabis.Plant physiology · 2019Article
- From Bugs to Bioplastics: Total (+)-Dihydrocarvide Biosynthesis by Engineered Escherichia coli.Chembiochem : a European journal of chemical biology · 2019Article
- Article
- Overexpression ofInternational journal of molecular sciences · 2018Article
- Functional Analysis of Four Terpene Synthases in Rose-Scented Pelargonium Cultivars (Frontiers in plant science · 2018Article
37 more citing papers are in PubMed but not listed here.
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Functional genomics approaches, which use combined computational and expression-based analyses of large amounts of sequence information, are emerging as powerful tools to accelerate the comprehensive understanding of cellular metabolism in specialized tissues and whole organisms. As part of an ongoing effort to identify genes of essential oil (monoterpene) biosynthesis, we have obtained sequence information from 1,316 randomly selected cDNA clones, or expressed sequence tags (ESTs), from a peppermint (Mentha x piperita) oil gland secretory cell cDNA library. After bioinformatic selection, candidate genes putatively involved in essential oil biosynthesis and secretion have been subcloned into suitable expression vectors for functional evaluation in Escherichia coli. On the basis of published and preliminary data on the functional properties of these clones, it is estimated that the ESTs involved in essential oil metabolism represent about 25% of the described sequences. An additional 7% of the recognized genes code for proteins involved in transport processes, and a subset of these is likely involved in the secretion of essential oil terpenes from the site of synthesis to the storage cavity of the oil glands. The integrated approaches reported here represent an essential step toward the development of a metabolic map of oil glands and provide a valuable resource for defining molecular targets for the genetic engineering of essential oil formation.
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