ArticleThe EMBO journal2000
Receptor recognition by a hepatitis B virus reveals a novel mode of high affinity virus-receptor interaction.
Article in The EMBO journal, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
24 citing papers in PubMed, 55 citations in OpenAlex.
- Phosphorylation of the Hepatitis B Virus Large Envelope Protein.Frontiers in molecular biosciences · 2021Article
- From DCPD to NTCP: the long journey towards identifying a functional hepatitis B virus receptor.Clinical and molecular hepatology · 2015Review
- Phage display creates innovative applications to combat hepatitis B virus.World journal of gastroenterology · 2014Review
- Sodium taurocholate cotransporting polypeptide mediates woolly monkey hepatitis B virus infection of Tupaia hepatocytes.Journal of virology · 2013Article
- Initiation of duck hepatitis B virus infection requires cleavage by a furin-like protease.Journal of virology · 2010Article
- The pre-S1 and antigenic loop infectivity determinants of the hepatitis B virus envelope proteins are functionally independent.Journal of virology · 2009Article
- Peroxisome proliferator-activated receptors in HBV-related infection.PPAR research · 2009Article
- Heterologous replacement of the supposed host determining region of avihepadnaviruses: high in vivo infectivity despite low infectivity for hepatocytes.PLoS pathogens · 2008Article
- Serum levels of preS antigen (HBpreSAg) in chronic hepatitis B virus infected patients.Virology journal · 2007Article
- Infectivity determinants of the hepatitis B virus pre-S domain are confined to the N-terminal 75 amino acid residues.Journal of virology · 2007Article
- Two potentially important elements of the hepatitis B virus large envelope protein are dispensable for the infectivity of hepatitis delta virus.Journal of virology · 2007Article
- Viral and cellular determinants involved in hepadnaviral entry.World journal of gastroenterology · 2007Review
- Avian hepatitis B viruses: molecular and cellular biology, phylogenesis, and host tropism.World journal of gastroenterology · 2007Review
- Mapping of the hepatitis B virus pre-S1 domain involved in receptor recognition.Journal of virology · 2005Article
- Identification and characterization of avihepadnaviruses isolated from exotic anseriformes maintained in captivity.Journal of virology · 2005Article
- Efficient inhibition of hepatitis B virus infection by acylated peptides derived from the large viral surface protein.Journal of virology · 2005Article
- Itinerary of hepatitis B viruses: delineation of restriction points critical for infectious entry.Journal of virology · 2004Article
- Glycine decarboxylase mediates a postbinding step in duck hepatitis B virus infection.Journal of virology · 2004Article
- Evolution of cell recognition by viruses: a source of biological novelty with medical implications.Advances in virus research · 2003Review
- Inhibition of duck hepatitis B virus infection by a myristoylated pre-S peptide of the large viral surface protein.Journal of virology · 2002Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The duck hepatitis B virus model system was used to elucidate the characteristics of receptor (carboxypeptidase D, gp180) interaction with polypeptides representing the receptor binding site in the preS part of the large viral surface protein. We demonstrate the pivotal role of carboxypeptidase D for virus entry and show its C-domain represents the virus attachment site, which binds preS with extraordinary affinity. Combining results from surface plasmon resonance spectroscopy and two-dimensional NMR analysis we resolved the contribution of preS sequence elements to complex stability and show that receptor binding potentially occurs in two steps. Initially, a short alpha-helix in the C-terminus of the receptor binding domain facilitates formation of a primary complex. This complex is stabilized sequentially, involving approximately 60 most randomly structured amino acids preceding the helix. Thus, hepadnaviruses exhibit a novel mechanism of high affinity receptor interaction by conserving the potential to adapt structure during binding rather than to preserve it per se. We propose that this process represents an alternative strategy to escape immune surveillance and the evolutionary pressure inherent in the compact hepadnaviral genome organization.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.