ArticleProceedings of the National Academy of Sciences of the United States of America2000
Male-male competition magnifies inbreeding depression in wild house mice.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 88 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
88 citing papers in PubMed, 1 synthesis or guideline pooled it, 261 citations in OpenAlex.
- Sex-specific inbreeding depression: A meta-analysis.Ecology letters · 2022Pooled it
- Social Context Alters Chemical Signalling and Endocrine Profiles in Two Mouse Subspecies.Journal of chemical ecology · 2026Article
- Heat-load-dependent inbreeding depression for production traits in Italian Holstein cattle.Genetics, selection, evolution : GSE · 2026Article
- Pre- and post-copulatory traits are affected by experimental inbreeding, but they are not correlated.BMC biology · 2025Article
- Demography and environment modulate the effects of genetic diversity on extinction risk in a butterfly metapopulation.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Female behavior drives the formation of distinct social structures in C57BL/6J versus wild-derived outbred mice in field enclosures.BMC biology · 2024Article
- Re-wilding model organisms: Opportunities to test causal mechanisms in social determinants of health and aging.Neuroscience and biobehavioral reviews · 2023Review
- Female scent accelerates growth of juvenile male mice.Scientific reports · 2023Article
- Reduced genetic diversity of freshwater amphipods in rivers with increased levels of anthropogenic organic micropollutants.Evolutionary applications · 2022Article
- Friend virus severity is associated with male mouse social status and environmental temperature.Animal behaviour · 2022Article
- Regulation of Sexually Dimorphic Expression of Major Urinary Proteins.Frontiers in physiology · 2022Review
- The effect of inbreeding, body size and morphology on health in dog breeds.Canine medicine and genetics · 2021Article
- The crucial role of genome-wide genetic variation in conservation.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Pheromones that correlate with reproductive success in competitive conditions.Scientific reports · 2021Article
- Male pheromones and their reception by females are co-adapted to affect mating success in two subspecies of brown rats.Current zoology · 2021Article
- Host Genetic Diversity and Infectious Diseases. Focus on Wild Boar, Red Deer and Tuberculosis.Animals : an open access journal from MDPI · 2021Review
- Demography, genetics, and decline of a spatially structured population of lekking bird.Oecologia · 2021Article
- Genetic characterization and phylogenetic study of Lakor goat from Southwest Maluku Regency based on mitochondrial COI gene.Veterinary world · 2020Article
- Article
- Musculoskeletal mass and shape are correlated with competitive ability in male house mice (The Journal of experimental biology · 2020Article
28 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
The detrimental effects of inbreeding on vertebrates are well documented for early stages of the life cycle in the laboratory. However, the consequences of inbreeding on long-term survival and reproductive success (Darwinian fitness) are uncertain for vertebrates in the wild. Here, we report direct experimental evidence for vertebrates that competition increases the harmful effects of inbreeding on offspring survival and reproduction. We compared the fitness of inbred (from full-sib matings) and outbred wild house mice (Mus domesticus) in large, seminatural enclosures. Inbred males sired only one-fifth as many surviving offspring as outbred males because of their poor competitive ability and survivorship. In laboratory conditions, inbreeding had relatively minor effects on male reproductive success and no effect on survivorship. Seminatural conditions did not increase inbreeding depression for females, probably because females were not competing for any critical resources. The overall reduction in fitness from inbreeding was 57%, which is 4.5 times as great as previous estimates from the laboratory. These results have important implications for medicine, conservation, evolutionary biology, and functional genomics.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.