ArticleThe Plant cell2000
Arabidopsis ethylene-responsive element binding factors act as transcriptional activators or repressors of GCC box-mediated gene expression.
Article in The Plant cell, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 482 papers.
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Who cites it
482 citing papers in PubMed, 1,054 citations in OpenAlex.
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- 3D Chromatin Architecture Provides Insights Into Leaf Trait Variation Among Pear Species.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
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- Comprehensive Genome-Wide Analysis of the AP2/ERF Transcription Factor Family and Examination of Potential RegulatorsPlants (Basel, Switzerland) · 2026Article
- Unravelling the molecular mechanisms of vegetative-to-reproductive transition in Cynara cardunculus by RNA-Seq analysis.Plant molecular biology · 2026Article
- Genome-wide analysis of Alfalfa AP2/ERF gene family and abiotic stress response.Frontiers in plant science · 2026Article
- Transcriptomic analysis reveals light quality response and systemic nutrient allocation under monochromatic light environments in Nicotiana tabacum.BMC plant biology · 2025Article
- ERF3 represses SA pathway defense to modulate tradeoffs between biotic and abiotic stress responses in Arabidopsis.Plant cell reports · 2025Article
- Potential regulatory modules to integrate microgravity signals into flowering pathways in Arabidopsis thaliana grown in space.NPJ microgravity · 2025Article
- Integrating ATAC-Seq and Pan-Genomics Identifies Stress-MemoryFood science & nutrition · 2025Article
- Two Transcriptional Factors Antagonistically Fine-Tune MIR1863a to Balance Resistance and Yield Traits in Rice.Plant biotechnology journal · 2025Article
- GmAP2 enhances plant tolerance to aluminum toxicity and phosphorus deficiency in Arabidopsis.Plant cell reports · 2025Article
- Better together: Subgenomes for allotetraploid potato wild relative Solanum acaule Bitt. reveal origins in Petota Clade 3 and 4.The plant genome · 2025Article
- Analysis of the AP2/ERF transcription factor family in Eriobotrya japonica and its role in exogenous melatonin-mediated regulation of salt stress.Functional & integrative genomics · 2025Article
- Downstream metabolites of (+)-cis-12-oxo-phytodienoic acid function as noncanonical bioactive jasmonates in Arabidopsis thaliana.Nature communications · 2025Article
- Are complex traits underpinned by polygenic molecular traits? A reflection on the complexity of gene expression.Plant & cell physiology · 2025Review
- Genome wide association study of Fusarium wilt resistance in Spinacia turkestanica.Scientific reports · 2025Article
422 more citing papers are in PubMed but not listed here.
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Ethylene-responsive element binding factors (ERFs) are members of a novel family of transcription factors that are specific to plants. A highly conserved DNA binding domain known as the ERF domain is the unique feature of this protein family. To characterize in detail this family of transcription factors, we isolated Arabidopsis cDNAs encoding five different ERF proteins (AtERF1 to AtERF5) and analyzed their structure, DNA binding preference, transactivation ability, and mRNA expression profiles. The isolated AtERFs were placed into three classes based on amino acid identity within the ERF domain, although all five displayed GCC box-specific binding activity. AtERF1, AtERF2, and AtERF5 functioned as activators of GCC box-dependent transcription in Arabidopsis leaves. By contrast, AtERF3 and AtERF4 acted as repressors that downregulated not only basal transcription levels of a reporter gene but also the transactivation activity of other transcription factors. The AtERF genes were differentially regulated by ethylene and by abiotic stress conditions, such as wounding, cold, high salinity, or drought, via ETHYLENE-INSENSITIVE2 (EIN2)-dependent or -independent pathways. Cycloheximide, a protein synthesis inhibitor, also induced marked accumulation of AtERF mRNAs. Thus, we conclude that AtERFs are factors that respond to extracellular signals to modulate GCC box-mediated gene expression positively or negatively.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.