ArticleJournal of bacteriology2000
The Bacillus subtilis HBsu protein modifies the effects of alpha/beta-type, small acid-soluble spore proteins on DNA.
Article in Journal of bacteriology, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed.
- Metagenomic approaches for studying ubiquitous yet diverse nucleoid associated proteins in microbial communities: challenges and advances.World journal of microbiology & biotechnology · 2025Review
- Acetylation of the histone-like protein HBsu at specific sites alters gene expression during sporulation inFrontiers in microbiology · 2025Article
- HU Knew? Bacillus subtilis HBsu Is Required for DNA Replication Initiation.Journal of bacteriology · 2022Article
- NFrontiers in microbiology · 2021Article
- Initiating ribosomes and a 5'/3'-UTR interaction control ribonuclease action to tightly couple B. subtilis hbs mRNA stability with translation.Nucleic acids research · 2017Article
- Molecular kinetics of reviving bacterial spores.Journal of bacteriology · 2013Article
- Disclosing the in vivo organization of a viral histone-like protein in Bacillus subtilis mediated by its capacity to recognize the viral genome.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- DNA clasping by mycobacterial HU: the C-terminal region of HupB mediates increased specificity of DNA binding.PloS one · 2010Article
- Cloning the hbs gene from Bacillus subtilis and expression of the HBsu protein in Escherichia coli.Iranian journal of microbiology · 2010Article
- DNA protection by histone-like protein HU from the hyperthermophilic eubacterium Thermotoga maritima.Nucleic acids research · 2008Article
- Surface salt bridges modulate the DNA site size of bacterial histone-like HU proteins.The Biochemical journal · 2005Article
- Genome wide, supercoiling-dependent in vivo binding of a viral protein involved in DNA replication and transcriptional control.Nucleic acids research · 2004Article
- Bacterial cold shock responses.Science progress · 2003Review
- Coping with the cold: the cold shock response in the Gram-positive soil bacterium Bacillus subtilis.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2002Review
- Growth phase variation in cell and nucleoid morphology in a Bacillus subtilis recA mutant.Journal of bacteriology · 2001Article
- Analysis of nucleoid morphology during germination and outgrowth of spores of Bacillus species.Journal of bacteriology · 2000Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
HBsu, the Bacillus subtilis homolog of the Escherichia coli HU proteins and the major chromosomal protein in vegetative cells of B. subtilis, is present at similar levels in vegetative cells and spores ( approximately 5 x 10(4) monomers/genome). The level of HBsu in spores was unaffected by the presence or absence of the alpha/beta-type, small acid-soluble proteins (SASP), which are the major chromosomal proteins in spores. In developing forespores, HBsu colocalized with alpha/beta-type SASP on the nucleoid, suggesting that HBsu could modulate alpha/beta-type SASP-mediated properties of spore DNA. Indeed, in vitro studies showed that HBsu altered alpha/beta-type SASP protection of pUC19 from DNase digestion, induced negative DNA supercoiling opposing alpha/beta-type SASP-mediated positive supercoiling, and greatly ameliorated the alpha/beta-type SASP-mediated increase in DNA persistence length. However, HBsu did not significantly interfere with the alpha/beta-type SASP-mediated changes in the UV photochemistry of DNA that explain the heightened resistance of spores to UV radiation. These data strongly support a role for HBsu in modulating the effects of alpha/beta-type SASP on the properties of DNA in the developing and dormant spore.
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Registered trials
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