Trial reportPharmaceutical research2000
Population pharmacokinetics of fast release oral diclofenac in healthy volunteers: relation to pharmacodynamics in an experimental pain model.
Trial report in Pharmaceutical research, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
9 citing papers in PubMed, 51 citations in OpenAlex.
- Evaluation of statistical power function for various diclofenac bioequivalence trials with different subject numbers.European journal of drug metabolism and pharmacokineticsTrial
- [Pharmacological aspects of pain research in Germany].Schmerz (Berlin, Germany) · 2015Review
- Advances in NSAID development: evolution of diclofenac products using pharmaceutical technology.Drugs · 2015Review
- Electroencephalography and analgesics.British journal of clinical pharmacology · 2014Review
- Understanding the hysteresis loop conundrum in pharmacokinetic/pharmacodynamic relationships.Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques · 2014Article
- Design of biorelevant test setups for the prediction of diclofenac in vivo features after oral administration.Pharmaceutical research · 2013Article
- Ultrasound-mediated drug delivery for cardiovascular disease.Expert opinion on drug delivery · 2013Review
- A new approach to the compartmental analysis in pharmacokinetics: fractional time evolution of diclofenac.Journal of pharmacokinetics and pharmacodynamics · 2010Article
- Population pharmacokinetics of oral diclofenac for acute pain in children.British journal of clinical pharmacology · 2008Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposePopulation pharmacokinetics of a fast release diclofenac were assessed with special focus on pharmacodynamic implications.
methodsIn a double blind four-way crossover study, 20 healthy volunteers received orally 50 and 100 mg diclofenac-Na effervescent ("fast-release NSAID"), 50 mg diclofenac tablets ("control"), or placebo. Population pharmacokinetics of the fast release diclofenac were assessed using a nonlinear mixed effects modeling approach (NON-MEM). Analgesic effects were investigated by means of an experimental pain model based on both pain-ratings and cortical evoked potentials after specific stimulation of nasal nociceptors with short pulses of gaseous CO2.
resultsPharmacokinetics of fast release diclofenac were best described by a two-compartment population model, with an estimated terminal half-life of 1.2 hours. Pharmacokinetics of diclofenac tablets were highly variable and a population pharmacokinetic model could not be obtained. As an indication of an early onset of analgesic effects, 100 mg fast release diclofenac but not the tablets significantly reduced the amplitudes of pain-related evoked potentials at 30 min after administration.
conclusionsEarlier drug absorption and lower pharmacokinetic variability of the fast-release formulation are likely to be preserved in a population.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.