ArticleThe Journal of physiology2000
Ventilatory and central neurochemical reorganisation of O2 chemoreflex after carotid sinus nerve transection in rat.
Article in The Journal of physiology, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 64 citations in OpenAlex.
- Ventilatory responses during and following hypercapnic gas challenge are impaired in male but not female endothelial NOS knock-out mice.Scientific reports · 2021Article
- Short-term facilitation of breathing upon cessation of hypoxic challenge is impaired in male but not female endothelial NOS knock-out mice.Scientific reports · 2021Article
- Carotid sinus nerve transection abolishes the facilitation of breathing that occurs upon cessation of a hypercapnic gas challenge in male mice.Journal of applied physiology (Bethesda, Md. : 1985) · 2021Article
- The Role of Carotid Sinus Nerve Input in the Hypoxic-Hypercapnic Ventilatory Response in Juvenile Rats.Frontiers in physiology · 2020Article
- Experimental Approach to Examine Leptin Signaling in the Carotid Bodies and its Effects on Control of Breathing.Journal of visualized experiments : JoVE · 2019Article
- Bilateral carotid sinus nerve transection exacerbates morphine-induced respiratory depression.European journal of pharmacology · 2018Article
- CrossTalk opposing view: the hypoxic ventilatory response does not include a central, excitatory hypoxia sensing component.The Journal of physiology · 2018Article
- Is plasticity within the retrotrapezoid nucleus responsible for the recovery of the PCO2 set-point after carotid body denervation in rats?The Journal of physiology · 2016Article
- Role of autonomic reflex arcs in cardiovascular responses to air pollution exposure.Cardiovascular toxicology · 2015Review
- Acrolein inhalation alters arterial blood gases and triggers carotid body-mediated cardiovascular responses in hypertensive rats.Inhalation toxicology · 2015Article
- Role of nitric oxide-containing factors in the ventilatory and cardiovascular responses elicited by hypoxic challenge in isoflurane-anesthetized rats.Journal of applied physiology (Bethesda, Md. : 1985) · 2014Article
- Hypoxia-induced ventilatory responses in conscious mice: gender differences in ventilatory roll-off and facilitation.Respiratory physiology & neurobiology · 2013Article
- Hemodynamic and ventilatory response to different levels of hypoxia and hypercapnia in carotid body-denervated rats.Clinics (Sao Paulo, Brazil) · 2013Article
- Acute and chronic effects of carotid body denervation on ventilation and chemoreflexes in three rat strains.The Journal of physiology · 2012Article
- Respiratory neuroplasticity following carotid body denervation: Central and peripheral adaptations.Neural regeneration research · 2012Article
- Antagonism of progesterone receptor suppresses carotid body responses to hypoxia and nicotine in rat pups.Neuroscience · 2012Article
- Breathing at high altitude.Cellular and molecular life sciences : CMLS · 2009Review
- Congenital hypoventilation and impaired hypoxic response in Nurr1 mutant mice.The Journal of physiology · 2004Article
- Phox2a gene, A6 neurons, and noradrenaline are essential for development of normal respiratory rhythm in mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2004Article
- Ventilatory responses and carotid body function in adult rats perinatally exposed to hyperoxia.The Journal of physiology · 2004Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
1. The first step of this study was to determine the early time course and pattern of hypoxic ventilatory response (HVR) recovery following irreversible bilateral carotid sinus nerve transection (CSNT). The second step was to find out if HVR recovery was associated with changes in the neurochemical activity of the medullary catecholaminergic cell groups involved in the O2 chemoreflex pathway. 2. The breathing response to acute hypoxia (10% O2) was measured in awake rats 2, 6, 10, 45 and 90 days after CSNT. In a control group of sham-operated rats, the ventilatory response to hypoxia was principally due to increased respiratory frequency. There was a large reduction in HVR in the CSNT compared to the sham-operated rats (-65%, 2 days after surgery). Within the weeks following denervation, the CSNT rats progressively recovered a HVR level similar to the sham-operated rats (-37% at 6 days, -27% at 10 days, and no difference at 45 or 90 days). After recovery, the CSNT rats exhibited a higher tidal volume (+38%) than the sham-operated rats in response to hypoxia, but not a complete recovery of respiratory frequency. 3. Fifteen days after CSNT, in vivo tyrosine hydroxylase (TH) activity had decreased in caudal A2C2 (-35%) and A6 cells (-35%). After 90 days, the CSNT rats displayed higher TH activity than the sham-operated animals in caudal A1C1 (+51%), caudal A2C2 (+129%), A5 (+216%) and A6 cells (+79%). 4. It is concluded that HVR following CSNT is associated with a profound functional reorganisation of the central O2 chemoreflex pathway, including changes in ventilatory pattern and medullary catecholaminergic activity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.